Evaluation of the ability of N-terminal fragment of lethal factor of Bacillus anthracis for delivery of Mycobacterium T cell antigen ESAT-6 into cytosol of antigen presenting cells to elicit effective cytotoxic T lymphocyte response

2006 ◽  
Vol 351 (3) ◽  
pp. 702-707 ◽  
Author(s):  
Subhash Chandra ◽  
Manpreet Kaur ◽  
Shuchi Midha ◽  
Rakesh Bhatnagar ◽  
Nirupama Banerjee-Bhatnagar
Keyword(s):  
T Cell ◽  
Bacillus Anthracis ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lethal Factor ◽  
Antigen Presenting Cells ◽  
Lymphocyte Response ◽  
Cell Antigen ◽  
Antigen Presenting ◽  
Cytotoxic T Lymphocyte Response

scholarly journals Dynamics of an HIV model with cytotoxic T-lymphocyte memory

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Chunhua Liu ◽  
Lei Kong
Keyword(s):  
T Cell ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Sufficient Conditions ◽  
Stable Limit Cycle ◽  
Stable Limit ◽  
Lymphocyte Response ◽  
Hiv Model ◽  
T Cell Help ◽  
Cytotoxic T Lymphocyte Response

Abstract We consider a four-dimensional HIV model that includes healthy cells, infected cells, primary cytotoxic T-lymphocyte response (CTLp), and secondary cytotoxic T-lymphocyte response (CTLe). The CTL memory generation depends on CD4+ T-cell help, and infection of CD4+ T cells results in impaired T-cell help. We show that the system has up to five equilibria. By the Routh–Hurwitz theorem and central manifold theorem we obtain some sufficient conditions for the local stability, globally stability of the equilibria, and the bifurcations. We still discover the bistability case where in the system there may coexist two stable equilibria or a stable equilibrium together with a stable limit cycle. Several numerical analyses are carried out to illustrate the validity of our theoretical results.

Sign in / Sign up

Export Citation Format

Share Document