α2-Adrenoceptor signaling in cardiomyocytes of spontaneously hypertensive rats starts to impair already at early age

2019 ◽  
Vol 512 (4) ◽  
pp. 908-913 ◽  
Author(s):  
A.V. Maltsev ◽  
E.V. Evdokimovskii ◽  
Y.M. Kokoz
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Early Age ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Α2 Adrenoceptor

scholarly journals Reduced α2-Adrenoceptor Binding in Lower Brainstem of Stroke-Prone Spontaneously Hypertensive Rats

1984 ◽  
Vol 35 (4) ◽  
pp. 468-470 ◽  
Author(s):  
Shizuo YAMADA ◽  
Tsuyoshi ISHIMA ◽  
Machiko HAYASHI ◽  
Takako TOMITA ◽  
Eiichi HAYASHI
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Α2 Adrenoceptor

Pathogenesis and Prevention of Stroke in Spontaneously Hypertensive Rats

1974 ◽  
Vol 48 (s2) ◽  
pp. 161s-163s ◽  
Author(s):  
K. Okamoto ◽  
F. Hazama ◽  
Y. Yamori ◽  
H. Haebara ◽  
A. Nagaoka
Keyword(s):  
Vascular Permeability ◽  
Spontaneously Hypertensive Rats ◽  
Selective Breeding ◽  
Severe Hypertension ◽  
Humoral Factor ◽  
Early Age ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Local Factors ◽  
Hypertensive Therapy

1. A colony of stroke-prone spontaneously hypertensive rats has been developed by selective breeding. 2. These animals developed severe hypertension early in life, the magnitude of the hypertension being closely related to the incidence of stroke. 3. No evidence was obtained of any humoral factor responsible for strokes. 4. Local factors predisposing to stroke were a scanty arterial supply with characteristic recurrent branching of long and large arteries, together with increased vascular permeability, angio-necrosis, and formation of microaneurysms. 5. Strokes could be prevented by adequate anti-hypertensive therapy from an early age.

Enhanced Inhibitory Effect of α2-Adrenoceptor Stimulation on the Formation of cAMP in Glomeruli of Spontaneously Hypertensive Rats

1992 ◽  
Vol 5 (8) ◽  
pp. 511-514
Author(s):  
Yuhong Liu ◽  
Satoshi Umemura ◽  
Nobuhito Hirawa ◽  
Yoshiyuki Toya ◽  
Kosuke Minamisawa ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Inhibitory Effect ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Α2 Adrenoceptor
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