scholarly journals Role of interleukin-25 in development of spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice

2017 ◽  
Vol 12 ◽  
pp. 62-65
Author(s):  
Yasuharu Abe ◽  
Aya Nambu ◽  
Sachiko Yamaguchi ◽  
Ayako Takamori ◽  
Hajime Suto ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Interleukin 25 ◽  
Deficient Mice

scholarly journals Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behçet’s disease

2018 ◽  
Vol 5 (1) ◽  
pp. 27-31
Author(s):  
Gul Dursun ◽  
Ayse Feyda Nursal ◽  
Helin Deniz Demir ◽  
Nevin Karakus ◽  
Osman Demir ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Interleukin 1 ◽  
Behcet's Disease ◽  
Interleukin 1 Receptor Antagonist

scholarly journals Role of endogenous interleukin‐1 receptor antagonist in regulating fever induced by localised inflammation in the rat

2001 ◽  
Vol 531 (1) ◽  
pp. 171-180 ◽  
Author(s):  
T. Cartmell ◽  
G. N. Luheshi ◽  
S. J. Hopkins ◽  
N. J. Rothwell ◽  
S. Poole
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist

Role of intracellular interleukin-1 receptor antagonist in skin carcinogenesis

2001 ◽  
Vol 30 (4) ◽  
pp. 218-223 ◽  
Author(s):  
Eunhye La ◽  
Joyce E. Rundhaug ◽  
Susan M. Fischer
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Skin Carcinogenesis ◽  
Interleukin 1 Receptor Antagonist

scholarly journals Toxoplasma gondii Infection Inhibits Th17-Mediated Spontaneous Development of Arthritis in Interleukin-1 Receptor Antagonist-Deficient Mice

2012 ◽  
Vol 80 (4) ◽  
pp. 1437-1444 ◽  
Author(s):  
Takuya Washino ◽  
Masataka Moroda ◽  
Yoichiro Iwakura ◽  
Fumie Aosai
Keyword(s):  
Toxoplasma Gondii ◽  
Receptor Antagonist ◽  
Th17 Cell ◽  
Interleukin 1 ◽  
Cell Polarization ◽  
Human Rheumatoid Arthritis ◽  
Th1 Cell ◽  
Content Type ◽  
Interleukin 1 Receptor Antagonist ◽  
Deficient Mice

ABSTRACTInterleukin 1 receptor antagonist (IL-1Ra)-deficient BALB/c mice develop spontaneous arthritis resembling human rheumatoid arthritis. We herein report that infection withToxoplasma gondii, an intracellular protozoan, is capable of ameliorating the spontaneous development of arthritis in IL-1Ra-deficient mice. The onset of arthritis development was delayed and the severity score of arthritis was significantly suppressed inT. gondii-infected mice. Expression of IL-12p40 mRNA from CD11c+cells of mesenteric lymph nodes (mLN) and spleen markedly increased at 1 week after peroral infection. While CD11c+cells also produced IL-10, IL-1β, and IL-6, CD4+T cells fromT. gondii-infected mice expressed significantly high levels of T-bet and gamma interferon (IFN-γ) mRNA in both mLN and spleen. Levels of GATA-3/IL-4 mRNA or RORγt/IL-17 mRNA decreased in the infected mice, indicating Th1 cell polarization and the reduction of Th2 and Th17 cell polarization. The severity of arthritis was related to Th1 cell polarization accompanied by Th17 cell reduction, demonstrating the protective role of theT. gondii-derived Th1 response against Th17 cell-mediated arthritis in IL-1Ra-deficient mice.

Prognostic role of interleukin-1B and interleukin-1-receptor antagonist polymorphisms in localized gastric cancer.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 10623-10623
Author(s):  
E. Goekkurt ◽  
G. Folprecht ◽  
S. Lehmann ◽  
L. Obermann ◽  
M. Kramer ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Prognostic Role ◽  
Interleukin 1 Receptor Antagonist
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