scholarly journals Role of Interleukin-1/Interleukin-1 Receptor Antagonist Family of Cytokines in Long-Term Continuous Glucose MonitoringIn Vivo

2013 ◽  
Vol 7 (6) ◽  
pp. 1538-1546 ◽  
Author(s):  
Ulrike Klueh ◽  
Omar Antar ◽  
Yi Qiao ◽  
Donald L. Kreutzer
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist

scholarly journals Role of interleukin-25 in development of spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice

2017 ◽  
Vol 12 ◽  
pp. 62-65
Author(s):  
Yasuharu Abe ◽  
Aya Nambu ◽  
Sachiko Yamaguchi ◽  
Ayako Takamori ◽  
Hajime Suto ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Interleukin 25 ◽  
Deficient Mice

scholarly journals Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behçet’s disease

2018 ◽  
Vol 5 (1) ◽  
pp. 27-31
Author(s):  
Gul Dursun ◽  
Ayse Feyda Nursal ◽  
Helin Deniz Demir ◽  
Nevin Karakus ◽  
Osman Demir ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Interleukin 1 ◽  
Behcet's Disease ◽  
Interleukin 1 Receptor Antagonist

scholarly journals Interleukin-1 Receptor Antagonist Synthesis by Peripheral Blood Mononuclear Cells

2000 ◽  
Vol 11 (11) ◽  
pp. 2114-2121
Author(s):  
VAIDYANATHAPURAM S. BALAKRISHNAN ◽  
CHRISTOPHER H. SCHMID ◽  
BERTRAND L. JABER ◽  
SVETLOZAR N. NATOV ◽  
ANDREW J. KING ◽  
...  
Keyword(s):  
Relative Risk ◽  
Receptor Antagonist ◽  
Clinical Outcomes ◽  
Peripheral Blood ◽  
Interleukin 1 ◽  
Peripheral Blood Mononuclear ◽  
Interleukin 1 Receptor Antagonist ◽  
Increased Risk

Abstract. Proinflammatory cytokines have been implicated in the short- and long-term morbidity experienced by hemodialysis (HD) patients. The present study, which is based on long-term follow-up of a cohort of 37 patients, relates peripheral blood mononuclear cell (PBMC) interleukin-1 receptor antagonist (IL-1Ra) synthesis (a reliable marker of IL-1β synthesis in HD patients) and plasma levels of an acute phase reactant, lipopolysaccharide binding protein (LBP), to clinical outcomes. In July 1993, predialysis blood samples from these patients were collected and IL-1Ra synthesis by PBMC and plasma LBP was measured. Hospital records were reviewed and patient follow-up data were obtained until December 1997 (54 mo) or death, whichever occurred earlier. The effect of age, diabetes, endotoxin- and IgG-stimulated IL-1Ra synthesis, and plasma LBP levels on mortality was assessed using the Cox proportional hazard regression model. Poisson regression was used to determine potential relationships between the number of outcome events and each continuous risk factor. Twenty-two patients (59%) died during the follow-up period. Mortality was unrelated to IL-1Ra synthesis but did increase with age (relative risk, 1.05/yr; P = 0.01) and diabetes (relative risk, 3.00/yr; P = 0.03). Cardiovascular event rates were higher among older individuals and in those with higher endotoxin-stimulated PBMC IL-1Ra synthesis. Cardiovascular events increased with plasma LBP levels in the range of 9,000 to 12,000 pg/ml but then seemed to decrease. In contrast, older age and low IgG-stimulated IL-1Ra synthesis were associated with an increased risk of infectious events. The results of this study demonstrate an interesting link between stimulus-dependent variability in IL-1Ra synthesis by PBMC and clinical outcomes among patients on chronic HD and provide interesting targets for therapeutic interventions in this vulnerable patient population.

scholarly journals Role of endogenous interleukin‐1 receptor antagonist in regulating fever induced by localised inflammation in the rat

2001 ◽  
Vol 531 (1) ◽  
pp. 171-180 ◽  
Author(s):  
T. Cartmell ◽  
G. N. Luheshi ◽  
S. J. Hopkins ◽  
N. J. Rothwell ◽  
S. Poole
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist

Role of intracellular interleukin-1 receptor antagonist in skin carcinogenesis

2001 ◽  
Vol 30 (4) ◽  
pp. 218-223 ◽  
Author(s):  
Eunhye La ◽  
Joyce E. Rundhaug ◽  
Susan M. Fischer
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Skin Carcinogenesis ◽  
Interleukin 1 Receptor Antagonist

Prognostic role of interleukin-1B and interleukin-1-receptor antagonist polymorphisms in localized gastric cancer.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 10623-10623
Author(s):  
E. Goekkurt ◽  
G. Folprecht ◽  
S. Lehmann ◽  
L. Obermann ◽  
M. Kramer ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Prognostic Role ◽  
Interleukin 1 Receptor Antagonist

68 Biological role of myeloid cell-derived interleukin-1 receptor antagonist in collagen-induced arthritis

Cytokine ◽  
2008 ◽  
Vol 43 (3) ◽  
pp. 252
Author(s):  
Celine Lamacchia ◽  
Gaby Palmer ◽  
Audrey Benoit ◽  
Dominique Talabot ◽  
Cem Gabay
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Myeloid Cell ◽  
Biological Role ◽  
Collagen Induced Arthritis ◽  
Interleukin 1 Receptor Antagonist

Long-Term Efficacy of Interleukin-1 Receptor Antagonist (Anakinra) in Corticosteroid-Dependent and Colchicine-Resistant Recurrent Pericarditis

2014 ◽  
Vol 164 (6) ◽  
pp. 1425-1431.e1 ◽  
Author(s):  
Martina Finetti ◽  
Antonella Insalaco ◽  
Luca Cantarini ◽  
Antonella Meini ◽  
Luciana Breda ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Recurrent Pericarditis ◽  
Interleukin 1 Receptor Antagonist ◽  
Term Efficacy
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