The Ca 2+ /CaMKK2 axis mediates the telbivudine induced upregulation of creatine kinase: Implications for mechanism of antiviral nucleoside analogs’ side effect

2017 ◽  
Vol 146 ◽  
pp. 224-232 ◽  
Author(s):  
Long Jianfei ◽  
Wang Min ◽  
Ma Chunlai ◽  
Chen Bicui ◽  
Zhang Jiming ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Side Effect ◽  
Nucleoside Analogs ◽  
Antiviral Nucleoside

Broad specificity of human phosphoglycerate kinase for antiviral nucleoside analogs

2004 ◽  
Vol 68 (9) ◽  
pp. 1749-1756 ◽  
Author(s):  
Sarah Gallois-Montbrun ◽  
Abdesslem Faraj ◽  
Edward Seclaman ◽  
Jean-Pierre Sommadossi ◽  
Dominique Deville-Bonne ◽  
...  
Keyword(s):  
Phosphoglycerate Kinase ◽  
Nucleoside Analogs ◽  
Antiviral Nucleoside ◽  
Broad Specificity

scholarly journals Statin-induced myopathy – a challenge for patients and physicians

2021 ◽  
Vol 16 (2) ◽  
pp. 148-152
Author(s):  
Gabriela Anca ANGELESCU ◽  
◽  
Mirela Marioara TOMA ◽  
Valentin VARLAS ◽  
◽  
...  
Keyword(s):  
Clinical Trials ◽  
Creatine Kinase ◽  
Side Effect ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Treatment Strategies ◽  
Density Lipoprotein ◽  
Review Article ◽  
Low Density

Statins are the most frequently used drugs for lowering the low density lipoprotein (LDL)-cholesterol and are proven to decrease the cardiovascular-driven mortality. The statin-induced myopathy represents a side effect of the statin therapy and includes heterogenous muscular symptoms, associated with an increase in the creatine kinase (CK) levels, according to clinical trials, at an incidence of 1.5-5%. The statin-induced myopathy is challenging for clinicians, in order to maintain the specific therapeutic approach for each case, as well as for patients at a high risk of cardiovascular diseases, who acknowledges the long-term benefits of the treatment. The aim of this review article is to showcase the types of statin-induced myopathy, the patient cohorts susceptible of developing this side effect and the treatment strategies for hypercholesterolemia/ dyslipidemia.

scholarly journals TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

2013 ◽  
Vol 41 (16) ◽  
pp. 7793-7803 ◽  
Author(s):  
S.-y. N. Huang ◽  
J. Murai ◽  
I. Dalla Rosa ◽  
T. S. Dexheimer ◽  
A. Naumova ◽  
...  
Keyword(s):  
Dna Damage ◽  
Mitochondrial Dna ◽  
Nucleoside Analogs ◽  
Mitochondrial Dna Damage ◽  
Antiviral Nucleoside

scholarly journals Antiviral nucleoside analogs

2021 ◽  
Author(s):  
Vladimir E. Kataev ◽  
Bulat F. Garifullin
Keyword(s):  
Nucleoside Analogs ◽  
Antiviral Nucleoside

scholarly journals Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase

2001 ◽  
Vol 276 (44) ◽  
pp. 40847-40857 ◽  
Author(s):  
Allison A. Johnson ◽  
Adrian S. Ray ◽  
Jeremiah Hanes ◽  
Zucai Suo ◽  
Joseph M. Colacino ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Nucleoside Analogs ◽  
Human Mitochondrial Dna ◽  
Mitochondrial Dna Polymerase ◽  
Antiviral Nucleoside
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