XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway

2021 ◽  
pp. 114513
Author(s):  
Dekun Gao ◽  
Hui Wu ◽  
Huiqun Jie ◽  
Min Liang ◽  
Dongzhen Yu ◽  
...  
Keyword(s):  
Hair Cell ◽  
Caspase 3 ◽  
Cell Damage ◽  
Hair Cell Damage

Hair Cell Damage in the Inner Ear of the Guinea Pig Due to Noise in a Workshop

1987 ◽  
Vol 103 (5) ◽  
pp. 204-211 ◽  
Author(s):  
B. Erlandsson ◽  
H. Hakanson ◽  
A. Ivarsson ◽  
P. Nilsson ◽  
J. Wersall
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Inner Ear ◽  
Cell Damage ◽  
Hair Cell Damage

Zebrafish swimming behavior as a biomarker for ototoxicity-induced hair cell damage: a high-throughput drug development platform targeting hearing loss

2015 ◽  
Vol 166 (5) ◽  
pp. 440-450 ◽  
Author(s):  
Maki Niihori ◽  
Terry Platto ◽  
Suzu Igarashi ◽  
Audriana Hurbon ◽  
Allison M. Dunn ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Drug Development ◽  
Hair Cell ◽  
High Throughput ◽  
Cell Damage ◽  
Swimming Behavior ◽  
Development Platform ◽  
Hair Cell Damage

In vivo assessment of hair cell damage and developmental toxicity caused by gestational caffeine exposure using zebrafish (Danio rerio) models

2017 ◽  
Vol 64 ◽  
pp. 1-7 ◽  
Author(s):  
Yoon Chan Rah ◽  
Myung Hoon Yoo ◽  
June Choi ◽  
Saemi Park ◽  
Hae-Chul Park ◽  
...  
Keyword(s):  
Hair Cell ◽  
Danio Rerio ◽  
Cell Damage ◽  
Developmental Toxicity ◽  
Hair Cell Damage ◽  
Caffeine Exposure ◽  
In Vivo Assessment

scholarly journals Involvement of ras activation in toxic hair cell damage of the mammalian cochlea

Neuroscience ◽  
2003 ◽  
Vol 122 (4) ◽  
pp. 1025-1035 ◽  
Author(s):  
A Battaglia ◽  
K Pak ◽  
D Brors ◽  
D Bodmer ◽  
J.A Frangos ◽  
...  
Keyword(s):  
Hair Cell ◽  
Cell Damage ◽  
Ras Activation ◽  
Hair Cell Damage

Early Evidence of Cochlear Damage in a Large Sample of Percussionists

2005 ◽  
Vol 20 (3) ◽  
pp. 135-139
Author(s):  
Jodee A Pride ◽  
David R Cunningham
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Otoacoustic Emissions ◽  
Outer Hair Cell ◽  
Cell Damage ◽  
Normal Hearing ◽  
Outer Hair Cells ◽  
Sensory Loss ◽  
Distortion Product ◽  
Hair Cell Damage

Percussionists can be exposed to intermittent sound stimuli that exceed 145 dB SPL, although damage may occur to the outer hair cells at levels of 120 dB SPL. The present study measured distortion-product otoacoustic emissions (DPOAEs) in a group of 86 normal-hearing percussionists and 39 normal-hearing nonpercussionists. Results indicate that normal-hearing percussionists have lower DPOAE amplitudes than normal-hearing nonpercussionists. DPOAE amplitudes were significantly lower at 6000 Hz in both the left and right ears for percussionists. Percussionists also more frequently had absent DPOAEs, with the greatest differences occurring at 6000 Hz (absent DPOAEs in 25% of percussionists vs 10% of nonpercussionists). When all frequencies are considered as a group, 33% of the percussionists had an absent DPOAE in either ear at some frequency, compared to only 23% of the nonpercussionists. Otoacoustic emissions are more sensitive to outer hair cell damage than pure-tone threshold measurements and can serve as an important measurement of sensory loss (i.e., outer hair cell damage) in musicians before the person perceives the hearing loss. DPOAE monitoring for musicians, along with appropriate education and intervention, might help prevent or minimize music-induced hearing loss.

Sign in / Sign up

Export Citation Format

Share Document