p53 protein activates the transcription of human proliferating cell nuclear antigen in response to 4-nitroquinoline N-oxide treatment

2005 ◽  
Vol 37 (2) ◽  
pp. 416-426 ◽  
Author(s):  
Yuanyuan Li ◽  
Lei Wang ◽  
Shihua Li ◽  
Tingqing Guo ◽  
Xiuyang Guo ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
P53 Protein ◽  
Nuclear Antigen ◽  
Proliferating Cell

p53 Protein and Proliferating Cell Nuclear Antigen in Eccrine Poroma and Porocarcinoma An Immunohistochemical Study

1995 ◽  
Vol 17 (5) ◽  
pp. 457-464 ◽  
Author(s):  
Hisashi Tateyama ◽  
Tadaaki Eimoto ◽  
Toyohiro Tada ◽  
Hiroshi Inagaki ◽  
Takaaki Nakamura ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Immunohistochemical Study ◽  
P53 Protein ◽  
Nuclear Antigen ◽  
Proliferating Cell ◽  
Eccrine Poroma

Changes in expression of p53, proliferating cell nuclear antigen and bcl-2 in recurrent laryngeal cancer after radiotherapy

2006 ◽  
Vol 120 (7) ◽  
pp. 579-582 ◽  
Author(s):  
B-J Lee ◽  
S-G Wang ◽  
H-J Roh ◽  
E-K Goh ◽  
K-M Chon ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Proliferating Cell Nuclear Antigen ◽  
P53 Protein ◽  
Significant Alteration ◽  
Nuclear Antigen ◽  
Immunohistochemical Stain ◽  
Proliferating Cell

The biological changes in recurrent laryngeal cancer following radiotherapy are not fully understood. The authors investigated differences in the expression of p53, proliferating cell nuclear antigen (PCNA) and bcl-2 in laryngeal cancer specimens before radiotherapy and in recurrent laryngeal cancer specimens following radiotherapy in the same patients. The authors investigated the expression of p53, PCNA and bcl-2 by immunohistochemical stain in 30 specimens from 15 patients with primary laryngeal cancer and recurrent laryngeal cancer after radiotherapy.The expression of p53 protein was significantly different in laryngeal cancer before radiotherapy (4/15, 26.7 per cent) compared with recurrent laryngeal cancer after radiotherapy (8/15, 53.3 per cent) (p < 0.05). The PCNA index was also significantly different in laryngeal cancer specimens before radiotherapy (mean, 11.9 per cent) compared with recurrent laryngeal cancer after radiotherapy (mean, 18.0 per cent) (p < 0.05). However, there was no statistically significant alteration of bcl-2 expression in primary compared with recurrent laryngeal cancer. The expression of p53 and PCNA increased in recurrent laryngeal cancers after radiotherapy, compared with that in laryngeal cancers before radiotherapy. Recurrent laryngeal cancers arising following radiotherapy became biologically aggressive.

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