Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery

Biomaterials ◽  
2009 ◽  
Vol 30 (29) ◽  
pp. 5691-5700 ◽  
Author(s):  
Lichen Yin ◽  
Jieying Ding ◽  
Chunbai He ◽  
Liming Cui ◽  
Cui Tang ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Drug Permeability ◽  
Trimethyl Chitosan

scholarly journals Oral insulin delivery by carboxymethyl-β-cyclodextrin-grafted chitosan nanoparticles for improving diabetic treatment

2018 ◽  
Vol 46 (sup3) ◽  
pp. S774-S782 ◽  
Author(s):  
Mingming Song ◽  
Hui Wang ◽  
Kuanmin Chen ◽  
Song Zhang ◽  
Lizhen Yu ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Diabetic Treatment

Enhanced stability of oral insulin in targeted peptide ligand trimethyl chitosan nanoparticles against trypsin

2015 ◽  
Vol 32 (7) ◽  
pp. 632-641 ◽  
Author(s):  
Jiexiu Chen ◽  
Chong Liu ◽  
Wei Shan ◽  
Zhijian Xiao ◽  
Han Guo ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Peptide Ligand ◽  
Oral Insulin ◽  
Trimethyl Chitosan ◽  
Enhanced Stability

Oral insulin delivery by self-assembled chitosan nanoparticles: In vitro and in vivo studies in diabetic animal model

2013 ◽  
Vol 33 (1) ◽  
pp. 376-382 ◽  
Author(s):  
Piyasi Mukhopadhyay ◽  
Kishor Sarkar ◽  
Mousumi Chakraborty ◽  
Sourav Bhattacharya ◽  
Roshnara Mishra ◽  
...  
Keyword(s):  
Animal Model ◽  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Diabetic Animal ◽  
In Vivo Studies ◽  
Oral Insulin ◽  
Self Assembled

scholarly journals Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery

2007 ◽  
Vol 24 (12) ◽  
pp. 2198-2206 ◽  
Author(s):  
B. Sarmento ◽  
A. Ribeiro ◽  
F. Veiga ◽  
P. Sampaio ◽  
R. Neufeld ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Oral Insulin

Strategies for effective oral insulin delivery with modified chitosan nanoparticles: A review

2012 ◽  
Vol 37 (11) ◽  
pp. 1457-1475 ◽  
Author(s):  
Piyasi Mukhopadhyay ◽  
Roshnara Mishra ◽  
Dipak Rana ◽  
Patit P. Kundu
Keyword(s):  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Modified Chitosan

Effect of insulin-loaded trimethyl chitosan nanoparticles on genes expression in the hippocampus of diabetic rats

2019 ◽  
Vol 31 (2) ◽  
Author(s):  
Giti Kalantarian ◽  
Nasrin Ziamajidi ◽  
Roghayeh Abbasalipourkabir ◽  
Reza Mahjub ◽  
Mohammad Taghi Goodarzi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Drug Loading ◽  
Chitosan Nanoparticles ◽  
Control Group ◽  
Complex Method ◽  
Oral Insulin ◽  
Trimethyl Chitosan ◽  
Significant Difference

AbstractBackgroundDiabetes mellitus is a chronic metabolic disorder that undesirably affects both central and peripheral nervous systems through the apoptosis of neurons. Insulin and insulin-like growth factors (IGFs) inhibit apoptosis of oligodendrocytes. The objective of this study was to determine whether oral insulin in the form of nanoparticles may have similar effects to injectable insulin in increasing the gene expression of IGF1 and IGF2.MethodsInsulin-loaded trimethyl chitosan nanoparticles were prepared using the polyelectrolyte complex method and characterized for size, polydispersity index, zeta potential, drug loading, and entrapment efficiency. An in vivo study was performed in different groups of male Wistar rats with diabetes mellitus type 1 treated with insulin-loaded trimethyl chitosan nanoparticles and subcutaneous injection of trade insulin (neutral protamine Hagedorn). The hippocampus of rats were studied for the expression of IGF1 and IGF2 genes by using real-time PCR, and the fold changes in gene expression were evaluated using the 2−ΔΔCt method.ResultsThe expression of IGF1 and IGF2 genes in the groups treated with nano-insulin and injected insulin were significantly higher than that in the diabetic control group (p<0.001) and meaningfully lower than that in the healthy control group. However, there was no significant difference to the treated groups.ConclusionOur findings suggest that future research might provide a new formulation of drugs for treating type 1 diabetes, in the form of oral insulin.

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