A gelatin-g-poly(N-isopropylacrylamide) biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine

Biomaterials ◽  
2012 ◽  
Vol 33 (7) ◽  
pp. 2372-2387 ◽  
Author(s):  
Jui-Yang Lai ◽  
Ai-Ching Hsieh
Keyword(s):  
Delivery System ◽  
In Situ Gelling

scholarly journals In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

2020 ◽  
Vol 10 (5-s) ◽  
pp. 32-39
Author(s):  
Fatima Eram ◽  
, Vivek
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Average Concentration ◽  
Posterior Segment ◽  
Ocular Infection ◽  
In Vivo Evaluation ◽  
Micro Emulsion ◽  
In Situ Gelling

Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid. Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug. The average concentration reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 µg/ml, which is far more than the concentration required for therapeutic effect (i.e.  >0.047 µg/ml or >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis). Conclusion: Thus, novel micro emulsion-based in situ gelling formulation could be a potential drug delivery system for the treatment of posterior segment diseases like endophthalmitis. Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

Injectable in situ gelling delivery system for the treatment of jawbone infections

2021 ◽  
Author(s):  
Shreshtha Dash ◽  
Somnath Singh ◽  
Alekha K Dash
Keyword(s):  
Lactic Acid ◽  
Sustained Release ◽  
Cell Viability ◽  
Yield Stress ◽  
Delivery System ◽  
Pluronic F127 ◽  
Sustained Delivery ◽  
In Situ Gelling ◽  
Sustained Rate

Aim: A polymeric in situ gelling delivery system for localized and sustained delivery to jawbone infections was developed. Materials & methods: In situ gelling delivery systems were prepared using either poly-dl-lactic acid or chitosan and Pluronic F127/Pluronic F68. Metronidazole nanoparticles were prepared using poly (dl-lactide-co-glycolide) or chitosan. Poly (dl-lactide-co-glycolide) was used for microparticles. Particles were characterized for size, charge and morphology. Results: Viscosity and yield stress of the gels were 0.4 Pa.s and 2 Pa, respectively, with 70% cell viability over 72 h. Around 90% of loaded metronidazole was released at a sustained rate over 1 week. Conclusion: Use of appropriate amount of nano/microparticles in the gel resulted in a sustained release over a period of 1 week – needed for jawbone infection.

Study of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin

2006 ◽  
Vol 315 (1-2) ◽  
pp. 12-17 ◽  
Author(s):  
Zhidong Liu ◽  
Jiawei Li ◽  
Shufang Nie ◽  
Hui Liu ◽  
Pingtian Ding ◽  
...  
Keyword(s):  
Delivery System ◽  
Ophthalmic Delivery ◽  
In Situ Gelling

Effect of carrageenan and potassium chloride on an in situ gelling ophthalmic drug delivery system based on methylcellulose

RSC Advances ◽  
2015 ◽  
Vol 5 (74) ◽  
pp. 60386-60391 ◽  
Author(s):  
Biplab Bhowmick ◽  
Gunjan Sarkar ◽  
Dipak Rana ◽  
Indranil Roy ◽  
Nayan Ranjan Saha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Potassium Chloride ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Model Drug ◽  
In Situ Gelling ◽  
Ophthalmic Formulation

Our research is devoted to developing a methylcellulose (MC) basedin situgelling ophthalmic formulation using pilocarpine hydrochloride as a model drug, containing different proportions of i (iota)-carrageenan and potassium chloride.

scholarly journals Research progress of in-situ gelling ophthalmic drug delivery system

2019 ◽  
Vol 14 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Yumei Wu ◽  
Yuanyuan Liu ◽  
Xinyue Li ◽  
Dereje Kebebe ◽  
Bing Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Research Progress ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
In Situ Gelling

A novel ion-activated in situ gelling ophthalmic delivery system based on κ-carrageenan for acyclovir

2017 ◽  
Vol 44 (5) ◽  
pp. 829-836 ◽  
Author(s):  
Pingfei Li ◽  
Shu Wang ◽  
Haoyuan Chen ◽  
Shiming Zhang ◽  
Shihui Yu ◽  
...  
Keyword(s):  
Delivery System ◽  
Ophthalmic Delivery ◽  
In Situ Gelling
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