Formulation of gastroretentive sustained release floating in situ gelling drug delivery system of solubility enhanced curcumin-soy lecithin complex

2019 ◽  
Vol 53 ◽  
pp. 101205 ◽  
Author(s):  
Harsha Kathpalia ◽  
Sonam Salunkhe ◽  
Siddhesh Juvekar
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Soy Lecithin ◽  
In Situ Gelling

Effect of carrageenan and potassium chloride on an in situ gelling ophthalmic drug delivery system based on methylcellulose

RSC Advances ◽  
2015 ◽  
Vol 5 (74) ◽  
pp. 60386-60391 ◽  
Author(s):  
Biplab Bhowmick ◽  
Gunjan Sarkar ◽  
Dipak Rana ◽  
Indranil Roy ◽  
Nayan Ranjan Saha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Potassium Chloride ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Model Drug ◽  
In Situ Gelling ◽  
Ophthalmic Formulation

Our research is devoted to developing a methylcellulose (MC) basedin situgelling ophthalmic formulation using pilocarpine hydrochloride as a model drug, containing different proportions of i (iota)-carrageenan and potassium chloride.

scholarly journals Research progress of in-situ gelling ophthalmic drug delivery system

2019 ◽  
Vol 14 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Yumei Wu ◽  
Yuanyuan Liu ◽  
Xinyue Li ◽  
Dereje Kebebe ◽  
Bing Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Research Progress ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
In Situ Gelling

scholarly journals Combination of Nanomicellar Technology and In Situ Gelling Polymer as Ocular Drug Delivery System (ODDS) for Cyclosporine-A

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 192
Author(s):  
Eleonora Terreni ◽  
Erica Zucchetti ◽  
Silvia Tampucci ◽  
Susi Burgalassi ◽  
Daniela Monti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cyclosporine A ◽  
Sol Gel ◽  
Ocular Drug Delivery ◽  
Water Soluble ◽  
Glycol Succinate ◽  
In Situ Gelling

A combination of in situ gelling systems and a loaded drug self-assembling nanomicellar carrier was chosen in this study as a new potential Ocular Drug Delivery System (ODDS) for Cyclosporine-A (CyA), a poorly water-soluble drug. Two non-ionic surfactants (d-α-tocopherol polyethylene glycol succinate, VitE-TPGS and polyoxyl 40 hydrogenated castor oil, RH-40) were used to produce the nanomicelles. The physical–chemical characterization of the nanomicelles in terms of CyA entrapment (EE%) and loading efficiency (LE%), cloud point (CP), regeneration time (RT), size and polydispersity index (PI) allowed us to select the best combination of surfactant mixture, which showed appropriate stability, high CyA-EE (99.07%), very small and homogeneous dimensions and favored the solubilization of an amount of CyA (0.144% w/w) comparable to that contained in marketed emulsion Ikervis®. The selected nanomicellar formulation incorporated into optimized ion-sensitive polymeric dispersions of gellan gum (GG-LA: 0.10, 0.15 and 0.20% w/w) able to trigger the sol–gel transition after instillation was characterized from technological (osmolality, pH, gelling capacity, rheological behavior, wettability, TEM and storage stability at 4 and 20 °C) and biopharmaceutical points of view. This new combined approach allowed us to obtain clear aqueous dispersions that were easy to instill and able to form a viscous gel when in contact with the tear fluid, improving CyA ocular bioavailability. Furthermore, this new ODDS prevented CyA transcorneal permeation, exhibited low cytotoxicity and prolonged the CyA resident time in the precorneal area compared to Ikervis®.

An In Situ Gelling Drug Delivery System for Improved Recovery after Spinal Cord Injury

2016 ◽  
Vol 5 (12) ◽  
pp. 1513-1521 ◽  
Author(s):  
Dongfei Liu ◽  
Tao Jiang ◽  
Weihua Cai ◽  
Jian Chen ◽  
Hongbo Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cord Injury ◽  
In Situ Gelling

scholarly journals Role of Micro Emulsion Based In-Situ Gelling System of Fluoroquinolone for Treatment of Posterior Segment Eye Diseases (PSED)

2020 ◽  
Vol 10 (3) ◽  
pp. 265-272
Author(s):  
Eram Fatima ◽  
Dr. Vivek
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Posterior Segment ◽  
Eye Diseases ◽  
Ocular Tissues ◽  
Micro Emulsion ◽  
Ophthalmic Drug ◽  
In Situ Gelling

The in situ drug delivery system and colloidal formulation like micro emulsion has potential to use in ocular delivery. Micro emulsion provides better permeation of drug through the membrane and provides improved bioavailability. The in situ drug delivery system decreases pre-corneal drainage, increase the contact time of formulation with eye and prolong the release in ocular tissues. Again, in situ gelling system has advantage of delivering accurate and reproducible quantities each time, against any already gelled formulations. To combine the benefits of these two dosage forms, micro emulsion based in situ gelling system can be developed as a novel vehicle for ophthalmic drug delivery. Endophthalmitis is an infection of intraocular fluids like vitreous humor and ocular tissues. To combat the disease, the formulation which provides sufficient concentration in posterior segment eye diseases (PSED) is required. Keywords: Posterior segment eye diseases, micro emulsion, drug delivery system, ocular, formulation.

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