RNAi functionalized collagen-chitosan/silicone membrane bilayer dermal equivalent for full-thickness skin regeneration with inhibited scarring

Biomaterials ◽  
2013 ◽  
Vol 34 (8) ◽  
pp. 2038-2048 ◽  
Author(s):  
Xing Liu ◽  
Lie Ma ◽  
Jun Liang ◽  
Bing Zhang ◽  
Jianying Teng ◽  
...  
Author(s):  
Yifeng Nie ◽  
Xinxiao Han ◽  
Zhuo Ao ◽  
Shangwei Ning ◽  
Xiang Li ◽  
...  

Gt–PCL composite materials, synthesized with polycaprplactone, gelatin and collagen, showed an improved epidermal healing rate and were able to respond and repair in advance.


Author(s):  
Lai Wei ◽  
Jianying Tan ◽  
Li Li ◽  
Sainan Liu ◽  
Huanran Wang ◽  
...  

The process of full-thickness skin regeneration is complex and has many parameters involved, which makes it difficult to use a single dressing to meet the various requirements of the complete regeneration at the same time. Therefore, developing hydrogel dressings with multifunction, including tunable rheological properties and aperture, hemostatic, antibacterial and super cytocompatibility, is a desirable candidate in wound healing. In this study, a series of complex hydrogels were developed via the hydrogen bond and covalent bond between chitosan (CS) and alginate (SA). These hydrogels exhibited suitable pore size and tunable rheological properties for cell adhesion. Chitosan endowed hemostatic, antibacterial properties and great cytocompatibility and thus solved two primary problems in the early stage of the wound healing process. Moreover, the sustained cytocompatibility of the hydrogels was further investigated after adding FGF and VE-cadherin via the co-culture of L929 and EC for 12 days. The confocal 3D fluorescent images showed that the cells were spherical and tended to form multicellular spheroids, which distributed in about 40-60μm thick hydrogels. Furthermore, the hydrogel dressings significantly accelerate defected skin turn to normal skin with proper epithelial thickness and new blood vessels and hair follicles through the histological analysis of in vivo wound healing. The findings mentioned above demonstrated that the CS/SA hydrogels with growth factors have tremendous potential as multifunctional hydrogel dressings for full-thickness skin regeneration incorporated with hemostatic, antibacterial, sustained cytocompatibility for 3D cell culture and normal skin repairing.


2016 ◽  
Vol 40 (12) ◽  
pp. E266-E279 ◽  
Author(s):  
Ali Samadikuchaksaraei ◽  
Ahmad Mehdipour ◽  
Mehryar Habibi Roudkenar ◽  
Javad Verdi ◽  
Mohammad Taghi Joghataei ◽  
...  

2012 ◽  
Vol 19 (7) ◽  
pp. 1321-1328
Author(s):  
Jae-Eun Chung ◽  
Yun-Jeong Kim ◽  
Yoon-Jeong Park ◽  
Ki-Tae Koo ◽  
Yang-Jo Seol ◽  
...  

Author(s):  
Rong Zhou ◽  
Lin Qiu ◽  
Jun Xiao ◽  
Xiaobo Mao ◽  
Xingang Yuan

Abstract The incidence of pediatric treadmill hand friction burns has been increasing every year. The injuries are deeper than thermal hand burns, the optimal treatment remains unclear. This was a retrospective study of children who received surgery for treadmill hand friction burns from January 1, 2015, to December 31, 2019, in a single burn center. A total of 22 children were surveyed. The patients were naturally divided into two groups: the wound repair group (13 patients), which was admitted early to the hospital after injury and received debridement and vacuum sealing drainage initially, and a full-thickness skin graft later; and the scar repair group (9 patients), in which a scar contracture developed as a result of wound healing and received scar release and skin grafting later. The Modified Michigan Hand Questionnaire score in the wound repair group was 116.31 ± 10.55, and the corresponding score in the scar repair group was 117.56 ± 8.85 (P>0.05), no statistically significant difference. The Vancouver Scar Scale score in the wound repair group was 4.15 ± 1.21, and the corresponding score in the scar repair group was 7.22 ± 1.09 (P<0.05). Parents were satisfied with the postoperative appearance and function of the hand. None in the two groups required secondary surgery. If the burns are deep second degree, third degree, or infected, early debridement, vacuum sealing drainage initially, and a full-thickness skin graft can obviously relieve pediatric pain, shorten the course of the disease, and restore the function of the hand as soon as possible.


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