composite hydrogels
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Soft Matter ◽  
2022 ◽  
Xiangqian Gao ◽  
Tiantian Deng ◽  
Xindi Huang ◽  
Mengmeng Yu ◽  
Danyang Li ◽  

A new composite hydrogels with excellent self-healing properties was prepared by combining poly(vinyl alcohol) (PVA) and boron nitride nanofibers (BNNFs) via a facile one-pot assembly method. One-dimensional porous BNNFs with...

2022 ◽  
Vol 122 ◽  
pp. 107116
Yi Zhang ◽  
Chen Li ◽  
Timothy Geary ◽  
Armando Jardim ◽  
Shudong He ◽  

Yili Wang ◽  
Feng Wen ◽  
Xueting Yao ◽  
Lulu Zeng ◽  
Jiaming Wu ◽  

A novel series of composite hydrogels, built from the three components 1), hyaluronic acid methacryloyl (HAMA); 2), gelatin methacryloyl (GelMA), and 3), extracellular cartilage matrix (ECM), was prepared and studied regarding the possible utility in the surgical repair of damaged (perforated) tympanic membrane (TM). Noteworthy is component 3), which was harvested from the ribs of α-1,3-galactosidyltransferase-knockout (α-1,3 GalT-KO) pigs. The absence of α-1,3-galactosyl glycoprotein is hypothesized to prevent rejection due to foreign-body immunogenicity. The composite hydrogels were characterized by various aspects, using a variety of physicochemical techniques: aqueous swelling, structural degradation, behavior under compression, and morphology, e.g., in vitro biocompatibility was assessed by the CCK-8 and live–dead assays and through cytoskeleton staining/microscopy. Alcian blue staining and real-time PCR (RT-PCR) were performed to examine the chondrogenic induction potential of the hydrogels. Moreover, a rat TM defect model was used to evaluate the in vivo performance of the hydrogels in this particular application. Taken together, the results from this study are surprising and promising. Much further development work will be required to make the material ready for surgical use.

Gels ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 6
Hiroyuki Takeno ◽  
Nagisa Suto

We investigated the mechanical and structural properties of composite hydrogels composed of chitosan nanofiber (ChsNF), positively charged alumina-coated silica (ac-SiO2) nanoparticles, carboxylated poly (vinyl alcohol) (cPVA), and borax. ChsNF/cPVA/borax hydrogels without ac-SiO2 exhibited high Young’s modulus but poor elongation, whereas cPVA/ac-SiO2/borax hydrogels without ChsNF had moderate Young’s modulus but high elongation. ChsNF/ac-SiO2/cPVA/borax hydrogels using both ChsNF and ac-SiO2 as reinforcement agents exhibited high extensibility (930%) and high Young′s modulus beyond 1 MPa at a high ac-SiO2 concentration. The network was formed by multiple crosslinking such as the complexation between borate and cPVA, the ionic complexation between ac-SiO2 and cPVA, and the hydrogen bond between ChsNF and cPVA. Structural analysis by synchrotron small-angle X-ray scattering revealed that the nanostructural inhomogeneity in ChsNF/ac-SiO2/cPVA/borax hydrogel was suppressed compared to those of the ChsNF/cPVA/borax and cPVA/ac-SiO2/borax hydrogels.

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