General cellular durotaxis induced with cell-scale heterogeneity of matrix-elasticity

Biomaterials ◽  
2020 ◽  
Vol 230 ◽  
pp. 119647 ◽  
Author(s):  
Hiroyuki Ebata ◽  
Kousuke Moriyama ◽  
Thasaneeya Kuboki ◽  
Satoru Kidoaki
Mathematics ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 460 ◽  
Author(s):  
Mahdi Rezapour ◽  
Khaled Ksaibati

There is growing interest in implementation of the mixed model to account for heterogeneity across population observations. However, it has been argued that the assumption of independent and identically distributed (i.i.d) error terms might not be realistic, and for some observations the scale of the error is greater than others. Consequently, that might result in the error terms’ scale to be varied across those observations. As the standard mixed model could not account for the aforementioned attribute of the observations, extended model, allowing for scale heterogeneity, has been proposed to relax the equal error terms across observations. Thus, in this study we extended the mixed model to the model with heterogeneity in scale, or generalized multinomial logit model (GMNL), to see if accounting for the scale heterogeneity, by adding more flexibility to the distribution, would result in an improvement in the model fit. The study used the choice data related to wearing seat belt across front-seat passengers in Wyoming, with all attributes being individual-specific. The results highlighted that although the effect of the scale parameter was significant, the scale effect was trivial, and accounting for the effect at the cost of added parameters would result in a loss of model fit compared with the standard mixed model. Besides considering the standard mixed and the GMNL, the models with correlated random parameters were considered. The results highlighted that despite having significant correlation across the majority of the random parameters, the goodness of fits favors more parsimonious models with no correlation. The results of this study are specific to the dataset used in this study, and due to the possible fact that the heterogeneity in observations related to the front-seat passengers seat belt use might not be extreme, and do not require extra layer to account for the scale heterogeneity, or accounting for the scale heterogeneity at the cost of added parameters might not be required. Extensive discussion has been made in the content of this paper about the model parameters’ estimations and the mathematical formulation of the methods.


2016 ◽  
Vol 4 (1) ◽  
pp. 9-26 ◽  
Author(s):  
Fengxuan Han ◽  
Caihong Zhu ◽  
Qianping Guo ◽  
Huilin Yang ◽  
Bin Li

The elasticity of the extracellular matrix has been increasingly recognized as a dominating factor of cell fate and activities. This review provides an overview of the general principles and recent advances in the field of matrix elasticity-dependent regulation of a variety of cellular activities and functions, the underlying biomechanical and molecular mechanisms, as well as the pathophysiological implications.


2017 ◽  
Vol 45 ◽  
pp. 75-87 ◽  
Author(s):  
Feng Gao ◽  
Jia Liu ◽  
J.G. Wang ◽  
Yang Ju ◽  
Chun Fai Leung

2008 ◽  
Vol 16 (7) ◽  
pp. 1251-1266 ◽  
Author(s):  
J. R. Hansen ◽  
V. Ernstsen ◽  
J. C. Refsgaard ◽  
S. Hansen

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