Injectable recombinant block polymer gel for sustained delivery of therapeutic protein in post traumatic osteoarthritis

Biomaterials ◽  
2022 ◽  
pp. 121370
Author(s):  
Priya Katyal ◽  
Aubryanna Hettinghouse ◽  
Michael Meleties ◽  
Sadaf Hasan ◽  
Changhong Chen ◽  
...  
Keyword(s):  
Therapeutic Protein ◽  
Sustained Delivery ◽  
Polymer Gel ◽  
Block Polymer ◽  
Post Traumatic

scholarly journals Anti-Inflammatory Therapeutic Approaches to Prevent or Delay Post-Traumatic Osteoarthritis (PTOA) of the Knee Joint with a Focus on Sustained Delivery Approaches

2021 ◽  
Vol 22 (15) ◽  
pp. 8005
Author(s):  
Christine M. Khella ◽  
Judith M. Horvath ◽  
Rojiar Asgarian ◽  
Bernd Rolauffs ◽  
Melanie L. Hart
Keyword(s):  
Knee Joint ◽  
Cartilage Degradation ◽  
Therapeutic Interventions ◽  
Sustained Delivery ◽  
Therapeutic Approaches ◽  
Joint Injury ◽  
Local Modes ◽  
Comprehensive Therapy ◽  
Post Traumatic ◽  
Anti Inflammatory

Inflammation plays a central role in the pathogenesis of knee PTOA after knee trauma. While a comprehensive therapy capable of preventing or delaying post-traumatic osteoarthritis (PTOA) progression after knee joint injury does not yet clinically exist, current literature suggests that certain aspects of early post-traumatic pathology of the knee joint may be prevented or delayed by anti-inflammatory therapeutic interventions. We discuss multifaceted therapeutic approaches that may be capable of effectively reducing the continuous cycle of inflammation and concomitant processes that lead to cartilage degradation as well as those that can simultaneously promote intrinsic repair processes. Within this context, we focus on early disease prevention, the optimal timeframe of treatment and possible long-lasting sustained delivery local modes of treatments that could prevent knee joint-associated PTOA symptoms. Specifically, we identify anti-inflammatory candidates that are not only anti-inflammatory but also anti-degenerative, anti-apoptotic and pro-regenerative.

Sustained delivery of pgrn-derivative atsttrin via e5c hydrogel protects cartilage and bone quality in a rabbit model of post-traumatic osteoarthritis

2021 ◽  
Vol 29 ◽  
pp. S193-S194
Author(s):  
A. Hettinghouse ◽  
P. Katyal ◽  
C. Chen ◽  
M. Cui ◽  
S. Hasan ◽  
...  
Keyword(s):  
Bone Quality ◽  
Rabbit Model ◽  
Sustained Delivery ◽  
Post Traumatic

Freeze-etch TEM of aqueous polymer gel network morphology

1986 ◽  
Vol 44 ◽  
pp. 796-797
Author(s):  
J. A. N. Zasadzinski ◽  
R. K. Prud'homme
Keyword(s):  
Metal Ion ◽  
Polymer Network ◽  
Polymer Gels ◽  
Polymer Gel ◽  
Deformation History ◽  
Crosslinked Polymer ◽  
Aqueous Polymer ◽  
History Of ◽  
Gel Network ◽  
Network Morphology

The rheological and mechanical properties of crosslinked polymer gels arise from the structure of the gel network. In turn, the structure of the gel network results from: thermodynamically determined interactions between the polymer chain segments, the interactions of the crosslinking metal ion with the polymer, and the deformation history of the network. Interpretations of mechanical and rheological measurements on polymer gels invariably begin with a conceptual model of,the microstructure of the gel network derived from polymer kinetic theory. In the present work, we use freeze-etch replication TEM to image the polymer network morphology of titanium crosslinked hydroxypropyl guars in an attempt to directly relate macroscopic phenomena with network structure.

Surgical Management of Post-Traumatic Neuropathic Pain

1991 ◽  
Vol 2 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Kim J. Burchiel ◽  
Jose L. Ochoa
Keyword(s):  
Neuropathic Pain ◽  
Surgical Management ◽  
Post Traumatic

Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions

2009 ◽  
pp. 090624002829090
Author(s):  
Tristan P. Learoyd ◽  
Jane L. Burrows ◽  
Eddie French ◽  
Peter C. Seville
Keyword(s):  
Sustained Delivery ◽  
Double Emulsions ◽  
Spray Dried

Review of Post-Traumatic Therapy and Victims of Violence.

1991 ◽  
Vol 36 (7) ◽  
pp. 641-641
Author(s):  
No authorship indicated
Keyword(s):  
Post Traumatic ◽  
Victims Of Violence
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