joint injury
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Development ◽  
2022 ◽  
Author(s):  
Ling Yu ◽  
Yu-Lieh Lin ◽  
Mingquan Yan ◽  
Tao Li ◽  
Emily Y. Wu ◽  
...  

Amputation injuries in mammals are typically non-regenerative, however joint regeneration is stimulated by BMP9 treatment (Yu et al., 2019) indicating the presence of latent articular chondrocyte progenitor cells. BMP9 induces a battery of chondrogenic genes in vivo, and a similar response is observed in cultures of amputation wound cells. Extended cultures of BMP9 treated cells results in differentiation of hyaline cartilage and single cell RNAseq analysis identified wound fibroblasts as BMP9 responsive. This culture model was used to identify a BMP9 responsive adult fibroblast cell line and a culture strategy was developed to engineer hyaline cartilage for engraftment into an acutely damaged joint. Transplanted hyaline cartilage survived engraftment and maintained a hyaline cartilage phenotype but did not form mature articular cartilage. In addition, individual hypertrophic chondrocytes were identified in some samples indicating that the acute joint injury site can promote osteogenic progression of engrafted hyaline cartilage. The findings identify fibroblasts as a cell source for engineering articular cartilage and establishes a novel experimental strategy that bridges the gap between regeneration biology and regenerative medicine.


2021 ◽  
Author(s):  
Jing Zeng ◽  
◽  
Qing Liu ◽  
Zhengfang Lei ◽  
Zhe Sun ◽  
...  

Review question / Objective: This study will provide new evidence for the effect of integrated neuromuscular training on the recovery of joint injury. Information sources: According to the PICOS principle, the third and fourth authors of this paper searched PsycINFO, Science direct, PubMed, Eric, Willey, China Knowledge Network (CNKI) Academic Journal Online Publishing General Library and China Knowledge Network (CNKI) excellent doctoral thesis full-text database by computer to collect relevant research on the impact of INT on joint injury repair. The time limit of injury retrieval is from the establishment of the database to December 2021.


2021 ◽  
Vol 9 (1) ◽  
pp. 200
Author(s):  
Jimmy Kuncoro ◽  
Muhammad Bayu Zohari Hutagalung ◽  
Dwikora Novembri Utomo

Post-traumatic osteoarthritis could emerge immediately after an injury or one year after a bone fracture, ligament injury, and meniscal tears. In this case report, we present a 30 years old male who previously suffered from joint injury and thus lost the ability to flexion. This patient has already under went internal bone implantation surgery involving the implantation but was removed due to pain, and there was protruding implant on the left knee. On physical examination, there was varus deformity with flexion ranged between 0-5°. On radiological examination, malunion and narrowing of the joint surface were, as shown, clinically inhibit the flexion of the knee. We diagnose the patient with malunion supracondylar femur sinistra and post traumatic osteoarthritis genu sinistra. Liberation procedure (soft tissues release) and osteotomy of the distal femur were performed on this patient. On post-op radiological examination, the implant successfully widens the joint surface and holds the fracture fragment after it was reduced. The joint was immediately mobilize using the machine. It was shown that in a relatively short period, the range of motion could reach 90°. Three months post-op, evaluation was done, and it was clearly shown that the range of motion had not decreased.


2021 ◽  
Vol 15 (3) ◽  
pp. 198-200
Author(s):  
Guillermo Martin Arrondo ◽  
Leandro Casola

The severity of hallux rigidus depends on the degree of joint involvement, from local pain to stress fractures of other bones of the foot due to hyper-support. Radiology is mandatory to have an accurate diagnosis and gives us a parameter of joint injury. We use the Coughlin and Shurnas classification as the gold standard for treatment. Level of Evidence IV.


2021 ◽  
Vol 57 (2) ◽  
pp. 173-184
Author(s):  
Petr Benda ◽  
Tereza Nováková ◽  
Lenka Žáková

Aims. The aim of this study was to clarify whether volleyball and handball players, as representatives of the so-called overhead athletes, already have an increased ROM and specific local hypermobility in the shoulder joints in the junior categories. These changes are described by goniometric measurements and hypermobility tests according to Sachse and Beighton. The results are examined with respect to gender and sport specialization. Methods. Ninety-five subjects without previous shoulder joint injury aged 16 to 19 years, including 73 volleyball and handball players, were tested. The cohort included 33 men, 40 women, 34 handball players and 39 volleyball players. The control group consisted of 22 participants, including 11 men and 11 women. The majority (90.5%) of the study participants were right-hand dominant. Only 9.5% of the participants were left-handed. Measurements were taken with a goniometer with digital display and hypermobility tests according to Sachse and Beighton. Results. In a selected group of volleyball and handball players, the ROM of the shoulder joints of the dominant arm was significantly greater in three ways: into extension, horizontal adduction and external rotation. On the other hand, the ROM of their shoulder joints in internal rotation is smaller and the research group has significant hypermobility in the glenohumeral (scapulohumeral) joint compared to the control group. Our study showed that females compared to males playing volleyball and handball have a significantly higher degree of internal rotation of both dominant and non-dominant arms. No significant differences were found when comparing volleyball and handball players. The difference in ROM between the dominant and non-dominant arms of volleyball and handball players was shown in extension and external rotation.


2021 ◽  
Vol 102 (6) ◽  
pp. 893-901
Author(s):  
O I Khokhlova ◽  
E M. Vasilchenko ◽  
A M. Berman

The study aimed to review the literature on the classical risk factors for knee osteoarthritis and their possible role in the development of this pathology in patients with unilateral transtibial amputation in terms of potential rehabilitation prospects. A search of publications was carried out using PubMed databases of the US National Center for Biotechnology Information and the website of the Elsevier publishing house. Well-established increased risk factors for knee osteoarthritis are old age, female gender, lower limb muscle weakness, low or excessive physical activity, overweight, a history of knee joint injury or surgery, chronic knee pain. These factors are common for disabled persons with unilateral transtibial amputation, which, combined with specific mechanical factors, makes these persons more vulnerable to the development and progression of osteoarthritis. Programs aimed at eliminating modifiable risk factors for the development of knee osteoarthritis can contribute to the preservation of knee joint function in the long term and improve the quality of life of persons with unilateral transtibial amputation. This requires the well-coordinated efforts of a multidisciplinary team, as well as the participation of the disabled persons themselves. Identification and management of the potentially modifiable classical risk factors for the development of knee osteoarthritis are one of the promising pathways of rehabilitation of persons with unilateral transtibial amputation.


2021 ◽  
Author(s):  
Nuthan Jagadeesh ◽  
Sachindra Kapadi ◽  
Venkatesh Deva ◽  
Ankur Kariya

An anterior cruciate ligament(ACL) is one of the major stabilizers of the knee joint, injury to which can be quite dreadful even ending many sports careers if not properly treated. Knowledge of the risk factors contributing to ACL injury will help in identifying at-risk individuals and develop preventive strategies. The factors contributing to ACL injury are multi-factorial involving biomechanical, anatomical, hormonal, neuromuscular factors etc; and can be broadly classified as Intrinsic and Extrinsic factors. Intrinsic factors are mostly non-modifiable risk factors may be subdivided into anatomical, genetic, gender, previous ACL Injuries etc . Whereas Extrinsic factors are mostly modifiable risk factors include environmental factors, characteristic of surface and shoe, BMI and others. Anatomical risk factors can divided into tibial parameters like posterior tibial slope, medial tibial plateau depth etc ; femoral parameters like notch width, notch index etc.


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