scholarly journals Activation studies with amines and amino acids of the β-carbonic anhydrase from the pathogenic protozoan Leishmania donovani chagasi

2018 ◽  
Vol 78 ◽  
pp. 406-410 ◽  
Author(s):  
Andrea Angeli ◽  
William A. Donald ◽  
Seppo Parkkila ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Leishmania Donovani ◽  
Pathogenic Protozoan

scholarly journals Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi

2018 ◽  
Vol 26 (14) ◽  
pp. 4187-4190 ◽  
Author(s):  
Andrea Angeli ◽  
Marianne Kuuslahti ◽  
Seppo Parkkila ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Trypanosoma Cruzi ◽  
Pathogenic Protozoan

scholarly journals Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica with Amino Acids and Amines

Metabolites ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 26 ◽  
Author(s):  
Silvia Bua ◽  
Susanna Haapanen ◽  
Marianne Kuuslahti ◽  
Seppo Parkkila ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Life Cycle ◽  
Carbonic Anhydrase ◽  
Entamoeba Histolytica ◽  
Methyl Ethyl ◽  
Alkyl Amines ◽  
Natural Amino Acids ◽  
Ethyl Amine ◽  
Pathogenic Protozoan

The β-carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic protozoan Entamoeba histolytica, EhiCA, was investigated for its activation with a panel of natural and non-natural amino acids and amines. EhiCA was potently activated by D-His, D-Phe, D-DOPA, L- and D-Trp, L- and D-Tyr, 4-amino-L-Tyr, histamine and serotonin, with KAs ranging between 1.07 and 10.1 M. The best activator was D-Tyr (KA of 1.07 µM). L-Phe, L-DOPA, L-adrenaline, L-Asn, L-Asp, L-Glu and L-Gln showed medium potency activation, with KAs of 16.5–25.6 µM. Some heterocyclic- alkyl amines, such as 2-pyridyl-methyl/ethyl-amine and 4-(2-aminoethyl)-morpholine, were devoid of EhiCA activating properties with KAs > 100 µM. As CA activators have poorly been investigated for their interaction with protozoan CAs, our study may be relevant for an improved understanding of the role of this enzyme in the life cycle of E. histolytica.

Carbonic anhydrase activators: Activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines

2007 ◽  
Vol 17 (15) ◽  
pp. 4107-4112 ◽  
Author(s):  
Daniela Vullo ◽  
Alessio Innocenti ◽  
Isao Nishimori ◽  
Andrea Scozzafava ◽  
Kai Kaila ◽  
...  
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Human Isoforms

scholarly journals The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines

2012 ◽  
Vol 22 (20) ◽  
pp. 6324-6327 ◽  
Author(s):  
Daniela Vullo ◽  
Viviana De Luca ◽  
Andrea Scozzafava ◽  
Vincenzo Carginale ◽  
Mosè Rossi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase

The γ-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae is potently activated by amines and amino acids

2018 ◽  
Vol 77 ◽  
pp. 1-5 ◽  
Author(s):  
Andrea Angeli ◽  
Sonia Del Prete ◽  
William A. Donald ◽  
Clemente Capasso ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Vibrio Cholerae ◽  
Pathogenic Bacterium

Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines

2010 ◽  
Vol 18 (6) ◽  
pp. 2300-2303 ◽  
Author(s):  
Anthony Bertucci ◽  
Didier Zoccola ◽  
Sylvie Tambutté ◽  
Daniela Vullo ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase

Carbonic anhydrase activators: Activation of the archaeal β-class (Cab) and γ-class (Cam) carbonic anhydrases with amino acids and amines

2008 ◽  
Vol 18 (23) ◽  
pp. 6194-6198 ◽  
Author(s):  
Alessio Innocenti ◽  
Sabrina A. Zimmerman ◽  
Andrea Scozzafava ◽  
James G. Ferry ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Carbonic Anhydrases

scholarly journals Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors

Metabolites ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 36 ◽  
Author(s):  
Niccolò Chiaramonte ◽  
Maria Romanelli ◽  
Elisabetta Teodori ◽  
Claudiu Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Building Blocks ◽  
Carbonic Anhydrase Inhibitors
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