Carbonic anhydrase activators: Activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines

2007 ◽  
Vol 17 (15) ◽  
pp. 4107-4112 ◽  
Author(s):  
Daniela Vullo ◽  
Alessio Innocenti ◽  
Isao Nishimori ◽  
Andrea Scozzafava ◽  
Kai Kaila ◽  
...  
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Human Isoforms

scholarly journals The Effect of Nanoparticles on the Structure and Enzymatic Activity of Human Carbonic Anhydrase I and II

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4405
Author(s):  
Celia Cabaleiro-Lago ◽  
Martin Lundqvist
Keyword(s):  
Carbonic Anhydrase ◽  
Conformational Changes ◽  
Catalytic Efficiency ◽  
The Body ◽  
Carbonic Anhydrases ◽  
Nanoparticle Surface ◽  
Mountain Sickness ◽  
Obesity And Cancer ◽  
Final Effect ◽  
Human Isoforms

Human carbonic anhydrases (hCAs) belong to a well characterized group of metalloenzymes that catalyze the conversion of carbonic dioxide into bicarbonate. There are currently 15 known human isoforms of carbonic anhydrase with different functions and distribution in the body. This links to the relevance of hCA variants to several diseases such as glaucoma, epilepsy, mountain sickness, ulcers, osteoporosis, obesity and cancer. This review will focus on two of the human isoforms, hCA I and hCA II. Both are cytosolic enzymes with similar topology and 60% sequence homology but different catalytic efficiency and stability. Proteins in general adsorb on surfaces and this is also the case for hCA I and hCA II. The adsorption process can lead to alteration of the original function of the protein. However, if the function is preserved interesting biotechnological applications can be developed. This review will cover the knowledge about the interaction between hCAs and nanomaterials. We will highlight how the interaction may lead to conformational changes that render the enzyme inactive. Moreover, the importance of different factors on the final effect on hCAs, such as protein stability, protein hydrophobic or charged patches and chemistry of the nanoparticle surface will be discussed.

scholarly journals The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines

2012 ◽  
Vol 22 (20) ◽  
pp. 6324-6327 ◽  
Author(s):  
Daniela Vullo ◽  
Viviana De Luca ◽  
Andrea Scozzafava ◽  
Vincenzo Carginale ◽  
Mosè Rossi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase

The γ-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae is potently activated by amines and amino acids

2018 ◽  
Vol 77 ◽  
pp. 1-5 ◽  
Author(s):  
Andrea Angeli ◽  
Sonia Del Prete ◽  
William A. Donald ◽  
Clemente Capasso ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Vibrio Cholerae ◽  
Pathogenic Bacterium

Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines

2010 ◽  
Vol 18 (6) ◽  
pp. 2300-2303 ◽  
Author(s):  
Anthony Bertucci ◽  
Didier Zoccola ◽  
Sylvie Tambutté ◽  
Daniela Vullo ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase

Carbonic anhydrase activators: Activation of the archaeal β-class (Cab) and γ-class (Cam) carbonic anhydrases with amino acids and amines

2008 ◽  
Vol 18 (23) ◽  
pp. 6194-6198 ◽  
Author(s):  
Alessio Innocenti ◽  
Sabrina A. Zimmerman ◽  
Andrea Scozzafava ◽  
James G. Ferry ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Carbonic Anhydrases

scholarly journals Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors

Metabolites ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 36 ◽  
Author(s):  
Niccolò Chiaramonte ◽  
Maria Romanelli ◽  
Elisabetta Teodori ◽  
Claudiu Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Building Blocks ◽  
Carbonic Anhydrase Inhibitors

Carbonic anhydrase activators: An activation study of the human mitochondrial isoforms VA and VB with amino acids and amines

2007 ◽  
Vol 17 (5) ◽  
pp. 1336-1340 ◽  
Author(s):  
Daniela Vullo ◽  
Isao Nishimori ◽  
Alessio Innocenti ◽  
Andrea Scozzafava ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase

Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines

2009 ◽  
Vol 19 (13) ◽  
pp. 3430-3433 ◽  
Author(s):  
Alessio Innocenti ◽  
Mika Hilvo ◽  
Seppo Parkkila ◽  
Andrea Scozzafava ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase
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