Discovery and optimization of novel phenyldiazepine and pyridodiazepine based Aurora kinase inhibitors

2020 ◽  
Vol 99 ◽  
pp. 103800
Author(s):  
Natarajan Tamizharasan ◽  
Chandru Gajendran ◽  
Rajendra Kristam ◽  
Suresh P. Sulochana ◽  
Dhanalakshmi Sivanandhan ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Aurora Kinase Inhibitors

Aurora Kinase Inhibitors in Head and Neck Cancer

2018 ◽  
Vol 18 (3) ◽  
pp. 199-213
Author(s):  
Guangying Qi ◽  
Jing Liu ◽  
Sisi Mi ◽  
Takaaki Tsunematsu ◽  
Shengjian Jin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Cancer Therapy ◽  
Kinase Inhibitors ◽  
Biological Function ◽  
Aurora Kinase ◽  
Aurora Kinases ◽  
Related Research ◽  
Chemotherapy Drugs ◽  
Aurora Kinase Inhibitors

Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represent a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.

Discovery of novel 2,4-disubstituted pyrimidines as Aurora kinase inhibitors

2020 ◽  
Vol 30 (3) ◽  
pp. 126885 ◽  
Author(s):  
Yu Xu ◽  
Shu-Yi Hao ◽  
Xiu-Juan Zhang ◽  
Wen-Bo Li ◽  
Xue-Peng Qiao ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Aurora Kinase Inhibitors

Aurora Kinase Inhibitors

2007 ◽  
pp. 157-175
Author(s):  
Mitesh Borad ◽  
Steven Warner ◽  
Daniel Von Hoff
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Aurora Kinase Inhibitors

scholarly journals Update on Aurora Kinase Inhibitors in Gynecologic Malignancies

2008 ◽  
Vol 3 (3) ◽  
pp. 162-177 ◽  
Author(s):  
Xia Tao ◽  
Hye Chon ◽  
Siqing Fu ◽  
John Kavanagh ◽  
Wei Hu
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Gynecologic Malignancies ◽  
Aurora Kinase Inhibitors

Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors

2010 ◽  
Vol 20 (8) ◽  
pp. 2443-2447 ◽  
Author(s):  
Stéphanie Blanchard ◽  
Anthony D. William ◽  
Angeline C.-H. Lee ◽  
Anders Poulsen ◽  
Ee Ling Teo ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Aurora Kinase Inhibitors

Short and long-term tumor cell responses to Aurora kinase inhibitors

2009 ◽  
Vol 315 (7) ◽  
pp. 1085-1099 ◽  
Author(s):  
Megan R. Dreier ◽  
Aaron Z. Grabovich ◽  
Jamie D. Katusin ◽  
William R. Taylor
Keyword(s):  
Tumor Cell ◽  
Kinase Inhibitors ◽  
Aurora Kinase ◽  
Cell Responses ◽  
Aurora Kinase Inhibitors ◽  
Short And Long Term
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