Discovery of Novel Tubulin Inhibitors Targeting the Colchicine Binding Site via Virtual Screening, Structural Optimization and Antitumor Evaluation

2021 ◽  
pp. 105486
Author(s):  
Wei Liu ◽  
Hairui Jia ◽  
Minghao Guan ◽  
Minxuan Cui ◽  
Zhuxuan Lan ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Structural Optimization ◽  
Binding Site ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site ◽  
Antitumor Evaluation

scholarly journals Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures

2017 ◽  
Vol 9 (15) ◽  
pp. 1765-1794 ◽  
Author(s):  
Wenlong Li ◽  
Honghao Sun ◽  
Shengtao Xu ◽  
Zheying Zhu ◽  
Jinyi Xu
Keyword(s):  
Binding Site ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site ◽  
Privileged Structures

scholarly journals Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site

Molecules ◽  
2016 ◽  
Vol 21 (10) ◽  
pp. 1375 ◽  
Author(s):  
Mengqi Dong ◽  
Fang Liu ◽  
Hongyu Zhou ◽  
Shumei Zhai ◽  
Bing Yan
Keyword(s):  
Binding Site ◽  
Natural Product ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site ◽  
Privileged Scaffold

scholarly journals Abstract 4608: Colchicine binding site agents as potent tubulin inhibitors suppressing triple negative breast cancer

2019 ◽  
Author(s):  
Shanshan Deng ◽  
Hao Chen ◽  
Raisa Krutilina ◽  
Najah G. Albadari ◽  
Tiffany N. Seagroves ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Binding Site ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site

scholarly journals Abstract 4608: Colchicine binding site agents as potent tubulin inhibitors suppressing triple negative breast cancer

2019 ◽  
Author(s):  
Shanshan Deng ◽  
Hao Chen ◽  
Raisa Krutilina ◽  
Najah G. Albadari ◽  
Tiffany N. Seagroves ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Binding Site ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Tubulin Inhibitors ◽  
Colchicine Binding Site
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