antitumor evaluation Latest Research Papers

Abstract Cancer is the second leading cause of death worldwide. There is always a huge demand for novel anticancer. New series of pyrazole, pyridine, thiazole derivatives containing sulfonamide moiety were prepared and screened for their antitumor activity against breast cancer cell line (MCF-7). The results of this investigation revealed that compounds 3 and 8 had significant anticancer activity against the MCF-7 cancer cell line with IC50 values 19.2 and 14.2 μM, respectively, in relation to the standard drug, doxorubicin.

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Photochemical synthesis, intercalation with DNA and antitumor evaluation in vitro of benzo[d]thiazolo[3,2-a]quinolin-10-ium derivatives

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105267 ◽

2021 ◽

pp. 105267

Author(s):

Alina E. Saifutiarova ◽

Yuri V. Fedorov ◽

Vladimir B. Tsvetkov ◽

Dina A. Rustamova ◽

Elena N. Gulakova ◽

...

Keyword(s):

Photochemical Synthesis ◽

Antitumor Evaluation

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Novel diosgenin-1,4-quinone hybrids: Synthesis, antitumor evaluation, and mechanism studies

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2021.105993 ◽

2021 ◽

pp. 105993

Author(s):

Guolong Li ◽

Qi Li ◽

Haopeng Sun ◽

Wei Li

Keyword(s):

Antitumor Evaluation

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Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105239 ◽

2021 ◽

pp. 105239

Author(s):

Yuru Liang ◽

Mao Zhang ◽

Pengfei Zhou ◽

Mingming Liu ◽

Jianqi Li ◽

...

Keyword(s):

Tubulin Polymerization ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Antitumor Evaluation

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Design, synthesis and in vitro antitumor evaluation of novel pyrazole-benzimidazole derivatives

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2021.128097 ◽

2021 ◽

pp. 128097

Author(s):

Bo Ren ◽

Rong-Chun Liu ◽

Kegong Ji ◽

Jiang-Jiang Tang ◽

Jin-Ming Gao

Keyword(s):

Benzimidazole Derivatives ◽

Design Synthesis ◽

Antitumor Evaluation

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Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112951 ◽

2021 ◽

Vol 210 ◽

pp. 112951

Author(s):

Gui-Bin Liang ◽

Jian-Hua Wei ◽

Hong Jiang ◽

Ri-Zhen Huang ◽

Jing-Ting Qin ◽

...

Keyword(s):

Nuclear Dna ◽

Design Synthesis ◽

Antitumor Evaluation

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Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo[1,5-a]pyrimidine derivatives as potential c-Met inhibitors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2020.104356 ◽

2020 ◽

Vol 104 ◽

pp. 104356

Author(s):

Guolin Luo ◽

Yanxia Ma ◽

Xintong Liang ◽

Guoquan Xie ◽

Yingqi Luo ◽

...

Keyword(s):

Pyrimidine Derivatives ◽

Design Synthesis ◽

Antitumor Evaluation

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antitumor evaluation
Recently Published Documents

TOTAL DOCUMENTS

H-INDEX

Synthesis, in vitro and in silico antitumor evaluation of 3-(2,6-dichlorophenyl)-1,5-diphenylpentane-1,5-dione: Structure, spectroscopic, RDG, Hirshfeld and DFT based analyses

Discovery of Novel Tubulin Inhibitors Targeting the Colchicine Binding Site via Virtual Screening, Structural Optimization and Antitumor Evaluation

In vitro optimization, characterization and antitumor evaluation against colorectal cancer of a novel 5Fluorouracil fluorouracil oral nanosuspension using soy protein, polysaccharides-protein complexation, and in-situ gel formation

Synthesis, Molecular Docking, And Antitumor Evaluation of Some New Pyrazole, Pyridine, And Thiazole Derivatives Incorporating Sulfonamide Residue

Photochemical synthesis, intercalation with DNA and antitumor evaluation in vitro of benzo[d]thiazolo[3,2-a]quinolin-10-ium derivatives

Novel diosgenin-1,4-quinone hybrids: Synthesis, antitumor evaluation, and mechanism studies

Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors

Design, synthesis and in vitro antitumor evaluation of novel pyrazole-benzimidazole derivatives

Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA

Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo[1,5-a]pyrimidine derivatives as potential c-Met inhibitors

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antitumor evaluationRecently Published Documents

TOTAL DOCUMENTS

H-INDEX

Synthesis, in vitro and in silico antitumor evaluation of 3-(2,6-dichlorophenyl)-1,5-diphenylpentane-1,5-dione: Structure, spectroscopic, RDG, Hirshfeld and DFT based analyses

Discovery of Novel Tubulin Inhibitors Targeting the Colchicine Binding Site via Virtual Screening, Structural Optimization and Antitumor Evaluation

In vitro optimization, characterization and antitumor evaluation against colorectal cancer of a novel 5Fluorouracil fluorouracil oral nanosuspension using soy protein, polysaccharides-protein complexation, and in-situ gel formation

Synthesis, Molecular Docking, And Antitumor Evaluation of Some New Pyrazole, Pyridine, And Thiazole Derivatives Incorporating Sulfonamide Residue

Photochemical synthesis, intercalation with DNA and antitumor evaluation in vitro of benzo[d]thiazolo[3,2-a]quinolin-10-ium derivatives

Novel diosgenin-1,4-quinone hybrids: Synthesis, antitumor evaluation, and mechanism studies

Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors

Design, synthesis and in vitro antitumor evaluation of novel pyrazole-benzimidazole derivatives

Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA

Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo[1,5-a]pyrimidine derivatives as potential c-Met inhibitors

antitumor evaluation
Recently Published Documents