Prediction of the pharmacokinetics and pharmacodynamics of topiroxostat in humans by integrating the physiologically based pharmacokinetic model with the drug-target residence time model

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2019.109660 ◽

2020 ◽

Vol 121 ◽

pp. 109660 ◽

Author(s):

Zhiqiang Luo ◽

Guohua Yu ◽

Xing Han ◽

Tingting Yang ◽

Yanhua Ji ◽

...

Keyword(s):

Residence Time ◽

Drug Target ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Pharmacokinetics And Pharmacodynamics ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically based pharmacokinetic model development for trazodone: application to paediatric dose projection

10.26226/morressier.5971be87d462b80290b534f2 ◽

2017 ◽

Author(s):

F. Calisti

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Paediatric Dose

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Risk Assessment of Perfluorooctane Sulfonate (PFOS) using Dynamic Age Dependent Physiologically based Pharmacokinetic Model (PBPK) across human lifetime

Environmental Research ◽

10.1016/j.envres.2021.111287 ◽

2021 ◽

pp. 111287

Author(s):

Deepika Deepika ◽

Raju Prasad Sharma ◽

Marta Schuhmacher ◽

Vikas Kumar

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Model ◽

Perfluorooctane Sulfonate ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

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Human risk assessment of di-isobutyl phthalate through the application of a developed physiologically based pharmacokinetic model of di-isobutyl phthalate and its major metabolite mono-isobutyl phthalate

Archives of Toxicology ◽

10.1007/s00204-021-03057-5 ◽

2021 ◽

Author(s):

Seung-Hyun Jeong ◽

Ji-Hun Jang ◽

Hea-Young Cho ◽

Yong-Bok Lee

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Model ◽

Major Metabolite ◽

Physiologically Based Pharmacokinetic Model ◽

Human Risk Assessment ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically‐Based Pharmacokinetic Model for Alectinib, Ruxolitinib, and Panobinostat in The Presence of Cancer, Renal Impairment, and Hepatic Impairment

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2282 ◽

2021 ◽

Author(s):

Mo'tasem M. Alsmadi

Keyword(s):

Renal Impairment ◽

Hepatic Impairment ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Development of a Physiologically-Based Pharmacokinetic Model for Perchloroethylene Using Tissue Concentration-Time Data

Toxicology and Applied Pharmacology ◽

10.1006/taap.1994.1179 ◽

1994 ◽

Vol 128 (1) ◽

pp. 50-59 ◽

Author(s):

C.E. Dallas ◽

X.M. Chen ◽

K. Obarr ◽

S. Muralidhara ◽

P. Varkonyi ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Tissue Concentration ◽

Physiologically Based Pharmacokinetic Model ◽

Time Data ◽

Physiologically Based Pharmacokinetic ◽

Concentration Time ◽

Physiologically Based

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Development of a Physiologically Based Pharmacokinetic Model for Estradiol in Rats and Humans: A Biologically Motivated Quantitative Framework for Evaluating Responses to Estradiol and Other Endocrine-Active Compounds

Toxicological Sciences ◽

10.1093/toxsci/69.1.60 ◽

2002 ◽

Vol 69 (1) ◽

pp. 60-78 ◽

Author(s):

D. R. Plowchalk

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Active Compounds ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model

Drug Metabolism and Disposition ◽

10.1124/dmd.114.060046 ◽

2014 ◽

Vol 43 (2) ◽

pp. 217-226 ◽

Author(s):

Kazuhiko Shirota ◽

Makoto Kaneko ◽

Makoto Sasaki ◽

Kouichi Minato ◽

Akira Fujikata ◽

...

Keyword(s):

P38 Mapk ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

P38 Mapk Inhibitor ◽

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Development and Application of a Multiroute Physiologically Based Pharmacokinetic Model for Oxytetracycline in Dogs and Humans

Journal of Pharmaceutical Sciences ◽

10.1002/jps.24244 ◽

2015 ◽

Vol 104 (1) ◽

pp. 233-243 ◽

Author(s):

Zhoumeng Lin ◽

Mengjie Li ◽

Ronette Gehring ◽

Jim E. Riviere

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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An Updated Physiologically Based Pharmacokinetic Model for Hexachlorobenzene: Incorporation of Pathophysiological States following Partial Hepatectomy and Hexachlorobenzene Treatment

Toxicological Sciences ◽

10.1093/toxsci/kfj133 ◽

2006 ◽

Vol 91 (1) ◽

pp. 29-41 ◽

Author(s):

Yasong Lu ◽

Manupat Lohitnavy ◽

Micaela B. Reddy ◽

Ornrat Lohitnavy ◽

Amanda Ashley ◽

...

Keyword(s):

Partial Hepatectomy ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Prediction of Drug Disposition in Diabetic Patients by Means of a Physiologically Based Pharmacokinetic Model

Clinical Pharmacokinetics ◽

10.1007/s40262-014-0192-8 ◽

2014 ◽

Vol 54 (2) ◽

pp. 179-193 ◽

Author(s):

Jia Li ◽

Hai-fang Guo ◽

Can Liu ◽

Zeyu Zhong ◽

Li Liu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Drug Disposition ◽

Diabetic Patients ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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