scholarly journals Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways

2021 ◽  
Vol 143 ◽  
pp. 112204
Author(s):  
Yongqiang Li ◽  
Mingkai Xu ◽  
Yansheng Li ◽  
Zhichun Zhang ◽  
Wu Gu ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Signaling Pathways ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin C2

Role of Staphylococcal Enterotoxin B on the Differentiation of Regulatory T Cells in Nasal Polyposis

2014 ◽  
Vol 28 (1) ◽  
pp. e17-e24 ◽  
Author(s):  
Soo-Na Cho ◽  
Chang-Hwa Song ◽  
Jun Jin ◽  
Sung Ha Kim ◽  
Ki-Sang Rha ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Nasal Polyposis ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

scholarly journals MicroRNAs expression profile in CCR6+ regulatory T cells

2014 ◽  
Author(s):  
Juanjuan Zhao ◽  
Yongju Li ◽  
Yan Hu ◽  
Chao Chen ◽  
Ya Zhou ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Signaling Pathways ◽  
Expression Profile ◽  
Immune Cells ◽  
Potential Role ◽  
Biological Function ◽  
Fold Change ◽  
Insight Into

Backgroud: CCR6+ CD4+ regulatory T cells (CCR6+Tregs), a distinct Tregs subset, played an important role in various immune diseases. Recent evidence showed that microRNAs (miRNAs) are vital regulators in the function of immune cells. However, the potential role of miRNAs in the function of CCR6+Tregs remains largely unknown. In this study, we detected the expression profile of miRNAs in CCR6+ Tregs. Materials and Methods: The expression profile of miRNAs as well as genes in CCR6+Tregs or CCR6-Tregs from Balb/c mice were detected by microarray. The signaling pathways were analyzed using Keggs pathway library. Results: We found that there were 58 miRNAs significantly upregulated and 62 downregulated up to 2 fold in CCR6+Tregs compared with CCR6-Tregs. Moreover, 1391 genes were observed with 3 fold change and 20 signaling pathways were enriched using Keggs pathway library. Conclusion: The present data firstly showed CCR6+Tregs expressed specific miRNAs pattern, which provide an insight into the role of miRNAs in the biological function of distinct Tregs subsets.

scholarly journals MicroRNAs expression profile in CCR6+ regulatory T cells

2014 ◽  
Author(s):  
Juanjuan Zhao ◽  
Yongju Li ◽  
Yan Hu ◽  
Chao Chen ◽  
Ya Zhou ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Signaling Pathways ◽  
Expression Profile ◽  
Immune Cells ◽  
Potential Role ◽  
Biological Function ◽  
Fold Change ◽  
Insight Into

Backgroud: CCR6+ CD4+ regulatory T cells (CCR6+Tregs), a distinct Tregs subset, played an important role in various immune diseases. Recent evidence showed that microRNAs (miRNAs) are vital regulators in the function of immune cells. However, the potential role of miRNAs in the function of CCR6+Tregs remains largely unknown. In this study, we detected the expression profile of miRNAs in CCR6+ Tregs. Materials and Methods: The expression profile of miRNAs as well as genes in CCR6+Tregs or CCR6-Tregs from Balb/c mice were detected by microarray. The signaling pathways were analyzed using Keggs pathway library. Results: We found that there were 58 miRNAs significantly upregulated and 62 downregulated up to 2 fold in CCR6+Tregs compared with CCR6-Tregs. Moreover, 1391 genes were observed with 3 fold change and 20 signaling pathways were enriched using Keggs pathway library. Conclusion: The present data firstly showed CCR6+Tregs expressed specific miRNAs pattern, which provide an insight into the role of miRNAs in the biological function of distinct Tregs subsets.

scholarly journals Staphylococcal enterotoxin A–activated regulatory T cells promote allergen-specific T H 2 response to intratracheal allergen inoculation

2017 ◽  
Vol 139 (2) ◽  
pp. 508-518.e4 ◽  
Author(s):  
Wei-ping Zeng ◽  
Margaret M. McFarland ◽  
Baohua Zhou ◽  
Silva Holtfreter ◽  
Susan Flesher ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin A

scholarly journals Cutting Edge: PHLPP Regulates the Development, Function, and Molecular Signaling Pathways of Regulatory T Cells

2011 ◽  
Vol 186 (10) ◽  
pp. 5533-5537 ◽  
Author(s):  
Scott J. Patterson ◽  
Jonathan M. Han ◽  
Rosa Garcia ◽  
Kiran Assi ◽  
Tianyan Gao ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Signaling Pathways ◽  
Cutting Edge ◽  
Molecular Signaling ◽  
Molecular Signaling Pathways

scholarly journals Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Shannon M. Ruppert ◽  
Ben A. Falk ◽  
S. Alice Long ◽  
Paul L. Bollyky
Keyword(s):  
Extracellular Matrix ◽  
T Cells ◽  
Cell Death ◽  
Regulatory T Cells ◽  
Signaling Pathways ◽  
Cyclosporine A ◽  
Foxp3 Expression ◽  
Immunosuppressive Agent ◽  
Cross Linking ◽  
The Face

Cyclosporine A (CSA) is an immunosuppressive agent that specifically targets T cells and also increases the percentage of pro-tolerogenic CD4+Foxp3+ regulatory T cells (Treg) through unknown mechanisms. We previously reported that CD44, a receptor for the extracellular matrix glycosaminoglycan hyaluronan (HA), promotes Treg stability in IL-2-low environments. Here, we asked whether CD44 signaling also promotes Treg resistance to CSA. We found that CD44 cross-linking promoted Foxp3 expression and Treg viability in the setting of CSA treatment. This effect was IL-2 independent but could be suppressed using sc-355979, an inhibitor of Stat5-phosphorylation. Moreover, we found that inhibition of HA synthesis impairs Treg homeostasis but that this effect could be overcome with exogenous IL-2 or CD44-cross-linking. Together, these data support a model whereby CD44 cross-linking by HA promotes IL-2-independent Foxp3 expression and Treg survival in the face of CSA.

scholarly journals Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells

2020 ◽  
Vol 10 ◽  
Author(s):  
Hind Hussein ◽  
Sébastien Denanglaire ◽  
Frédéric Van Gool ◽  
Abdulkader Azouz ◽  
Yousra Ajouaou ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Signaling Pathways
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