OR.6. Selective Deregulation in Chemokine Signaling Pathways of CD4+CD25hiCD127lo/-Regulatory T Cells in Human Allergic Asthma

A mouse pulmonary hypersensitivity experimental model that mimics human asthma was developed, and electroacupuncture (EA) treatment was shown to reduce allergic inflammatory processes. In addition, we also assessed whether the beneficial effects of EA on allergic asthma could be correlated with CD4+CD25+Foxp3+regulatory T cells (Treg). Cellular profiles and histopathologic analysis demonstrated that peribronchial and perivascular inflammatory cell infiltrates were significantly decreased in the EA-treated groups when compared to the OVA and anti-CD25 Ab-injected (Treg depletion) groups. Furthermore, total BAL cells were reduced in the EA groups when compared to other groups. Interestingly, the population of CD4+CD25+Foxp3+Tregs in pneumonocytes increased in EA-treated group when compared to OVA and Treg depletion groups. These results imply that EA stimulation at ST 36 may affect CD4+CD25+Foxp3+Treg in an OVA-induced experimental model and may enhance Treg function by suppressing other T cells and limiting the immune response.

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Increase of Frequency and Modulation of Phenotype of Regulatory T Cells by Atorvastatin Is Associated with Decreased Lung Inflammatory Cell Infiltration in a Murine Model of Acute Allergic Asthma

Frontiers in Immunology ◽

10.3389/fimmu.2016.00620 ◽

2016 ◽

Vol 7 ◽

Cited By ~ 5

Author(s):

Yurany Blanquiceth ◽

Ana Lucia Rodríguez-Perea ◽

Jorge H. Tabares Guevara ◽

Luis Alfonso Correa ◽

María Dulfary Sánchez ◽

...

Keyword(s):

T Cells ◽

Regulatory T Cells ◽

Allergic Asthma ◽

Murine Model ◽

Inflammatory Cell ◽

Inflammatory Cell Infiltration ◽

Cell Infiltration

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Functional defects of CD46-induced regulatory T cells to suppress airway inflammation in mite allergic asthma

Laboratory Investigation ◽

10.1038/labinvest.2012.86 ◽

2012 ◽

Vol 92 (9) ◽

pp. 1260-1269 ◽

Cited By ~ 11

Author(s):

Yi-Giien Tsai ◽

Dau-Ming Niu ◽

Kuender D Yang ◽

Chih-Hsing Hung ◽

Ya-Ju Yeh ◽

...

Keyword(s):

T Cells ◽

Regulatory T Cells ◽

Airway Inflammation ◽

Allergic Asthma ◽

Functional Defects

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MicroRNAs expression profile in CCR6+ regulatory T cells

10.7287/peerj.preprints.471v2 ◽

2014 ◽

Author(s):

Juanjuan Zhao ◽

Yongju Li ◽

Yan Hu ◽

Chao Chen ◽

Ya Zhou ◽

...

Keyword(s):

T Cells ◽

Regulatory T Cells ◽

Signaling Pathways ◽

Expression Profile ◽

Immune Cells ◽

Potential Role ◽

Biological Function ◽

Fold Change ◽

Insight Into

Backgroud: CCR6+ CD4+ regulatory T cells (CCR6+Tregs), a distinct Tregs subset, played an important role in various immune diseases. Recent evidence showed that microRNAs (miRNAs) are vital regulators in the function of immune cells. However, the potential role of miRNAs in the function of CCR6+Tregs remains largely unknown. In this study, we detected the expression profile of miRNAs in CCR6+ Tregs. Materials and Methods: The expression profile of miRNAs as well as genes in CCR6+Tregs or CCR6-Tregs from Balb/c mice were detected by microarray. The signaling pathways were analyzed using Keggs pathway library. Results: We found that there were 58 miRNAs significantly upregulated and 62 downregulated up to 2 fold in CCR6+Tregs compared with CCR6-Tregs. Moreover, 1391 genes were observed with 3 fold change and 20 signaling pathways were enriched using Keggs pathway library. Conclusion: The present data firstly showed CCR6+Tregs expressed specific miRNAs pattern, which provide an insight into the role of miRNAs in the biological function of distinct Tregs subsets.

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