Synthesis, biological activity and structure–activity relationship of endomorphin-1/substance P derivatives

2012 ◽  
Vol 20 (21) ◽  
pp. 6335-6343 ◽  
Author(s):  
Pegah Varamini ◽  
Waleed M. Hussein ◽  
Friederike M. Mansfeld ◽  
Istvan Toth
Keyword(s):  
Biological Activity ◽  
Substance P ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Synthesis of Hippospongic Acid A Analogues Designed for Investigating the Structure-Activity Relationship of its Biological Activity

2000 ◽  
Vol 53 (12) ◽  
pp. 909 ◽  
Author(s):  
Yoshikazu Hiraga ◽  
Mariko Ago ◽  
Munetaka Tokumasu ◽  
Ken Kaku ◽  
Katsuo Ohkata
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Sea Urchin ◽  
Essential Feature ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Acid Moiety ◽  
Sea Urchin Embryos ◽  
Structure Activity ◽  
Relationship Of

Analogues of hippospongic acid A, which inhibit the gastrulation of sea urchin embryos, were synthesized. From a study on structure—activity relationships, the conjugated carboxylic acid moiety was found to be an essential feature for biological activity.

Expanding the structure-activity relationship of sulfoxaflor: the synthesis and biological activity ofN-heterocyclic sulfoximines

2014 ◽  
Vol 71 (7) ◽  
pp. 928-936 ◽  
Author(s):  
Benjamin M Nugent ◽  
Ann M Buysse ◽  
Michael R Loso ◽  
Jon M Babcock ◽  
Timothy C Johnson ◽  
...  
Keyword(s):  
Biological Activity ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Structure-Activity Relationship of Two Typical Amaryllidaceae Isocarbostyril Alkaloids and their Derivatives

2013 ◽  
Vol 411-414 ◽  
pp. 3158-3161 ◽  
Author(s):  
Yu Bin Ji ◽  
Yan Dong ◽  
Ning Chen ◽  
Dong Xue Song ◽  
Jia Zheng
Keyword(s):  
Biological Activity ◽  
Nuclear Structure ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Rational Basis ◽  
Structural Modifications ◽  
Structure Activity ◽  
Ring Junction ◽  
Relationship Of

This paper reviews the structure-activity relationship of two typical Amaryllidaceae isocarbostyril alkaloids, narciclasine, pancratistatin and their derivatives. Varieties structures have important impacts on biological activity of Amaryllidaceae isocarbostyril alkaloids, for example, the nuclear structure of isocarbostyril, the stereochemistry of the B/C ring junction, the C7-hydroxy of ring A, hydroxies of ring C and so on. This study is conducive to find other active groups, conduct structural modifications and provide the rational basis for designing drugs molecular.

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