Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif

Design, synthesis and biological evaluation of selective histone deacetylase 6 (HDAC6) inhibitors bearing benzoindazole or pyrazoloindazole scaffold as surface recognition motif

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104910 ◽

2021 ◽

pp. 104910

Author(s):

Qihao Xu ◽

Yanhua Mou ◽

Siyuan Wang ◽

Xiaoxiao Gao ◽

Yulong Zhang ◽

...

Keyword(s):

Histone Deacetylase ◽

Biological Evaluation ◽

Histone Deacetylase 6 ◽

Design Synthesis ◽

Recognition Motif ◽

Surface Recognition ◽

Design, synthesis, and biological evaluation of indole-based hydroxamic acid derivatives as histone deacetylase inhibitors

10.1016/j.ejmech.2021.113893 ◽

2022 ◽

Vol 227 ◽

pp. 113893

Author(s):

Bei-Er Jiang ◽

Jiaxin Hu ◽

Hao Liu ◽

Zhitao Liu ◽

Yu Wen ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b01194 ◽

2019 ◽

Vol 62 (23) ◽

pp. 10711-10739 ◽

Cited By ~ 10

Author(s):

Barbara Vergani ◽

Giovanni Sandrone ◽

Mattia Marchini ◽

Chiara Ripamonti ◽

Edoardo Cellupica ◽

...

Keyword(s):

Histone Deacetylase ◽

Biological Evaluation ◽

Histone Deacetylase 6 ◽

Scaffold Design ◽

Design Synthesis ◽

Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease

10.1016/j.ejmech.2018.03.005 ◽

2018 ◽

Vol 150 ◽

pp. 506-524 ◽

Cited By ~ 24

Author(s):

Obdulia Rabal ◽

Juan A. Sánchez-Arias ◽

Mar Cuadrado-Tejedor ◽

Irene de Miguel ◽

Marta Pérez-González ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Histone Deacetylase ◽

Biological Evaluation ◽

Histone Deacetylase 6 ◽

Selective Inhibitors ◽

Design Synthesis ◽

In Vivo Testing ◽

Phosphodiesterase 5

Correction to Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.9b00336 ◽

2019 ◽

Vol 10 (9) ◽

pp. 1358-1358 ◽

Cited By ~ 1

Author(s):

Taha Y. Taha ◽

Shaimaa M. Aboukhatwa ◽

Rachel C. Knopp ◽

Naohiko Ikegaki ◽

Hazem Abdelkarim ◽

...

Keyword(s):

Histone Deacetylase ◽

Biological Evaluation ◽

Selective Inhibitors ◽

Design Synthesis ◽

Histone Deacetylase 8 ◽

Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.7b00126 ◽

2017 ◽

Vol 8 (8) ◽

pp. 824-829 ◽

Cited By ~ 15

Author(s):

Taha Y. Taha ◽

Shaimaa M. Aboukhatwa ◽

Rachel C. Knopp ◽

Naohiko Ikegaki ◽

Hazem Abdelkarim ◽

...

Keyword(s):

Histone Deacetylase ◽

Biological Evaluation ◽

Selective Inhibitors ◽

Design Synthesis ◽

Histone Deacetylase 8 ◽

Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.08.030 ◽

2014 ◽

Vol 22 (21) ◽

pp. 6146-6155 ◽

Cited By ~ 13

Author(s):

Wei Yang ◽

Lixuan Li ◽

Xun Ji ◽

Xiaowei Wu ◽

Mingbo Su ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1

10.1016/j.ejmech.2020.112338 ◽

2020 ◽

Vol 200 ◽

pp. 112338

Author(s):

Ehab Ghazy ◽

Patrik Zeyen ◽

Daniel Herp ◽

Martin Hügle ◽

Karin Schmidtkunz ◽

...

Keyword(s):

Histone Deacetylase ◽

Biological Evaluation ◽

Histone Deacetylase 6 ◽

Design Synthesis ◽

Dual Targeting ◽

Hybrids from Farnesylthiosalicylic Acid and Hydroxamic Acid as Dual Ras-Related Signaling and Histone Deacetylase (HDAC) Inhibitors: Design, Synthesis and Biological Evaluation

ChemMedChem ◽

10.1002/cmdc.201500019 ◽

2015 ◽

Vol 10 (6) ◽

pp. 971-976 ◽

Cited By ~ 16

Author(s):

Yong Ling ◽

Xuemin Wang ◽

Chenniu Wang ◽

Chenjun Xu ◽

Wei Zhang ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Hdac Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors

10.1016/j.ejmech.2017.01.035 ◽

2017 ◽

Vol 128 ◽

pp. 293-299 ◽

Cited By ~ 13

Author(s):

Jiang Wang ◽

Mingbo Su ◽

Tingting Li ◽

Anhui Gao ◽

Wei Yang ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Hdac Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽