Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold

2018 ◽  
Vol 26 (12) ◽  
pp. 3619-3633 ◽  
Author(s):  
Hao Zhang ◽  
Jin Wang ◽  
Hong-Yi Zhao ◽  
Xue-Yan Yang ◽  
Hao Lei ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
Egfr Tyrosine Kinase ◽  
Egfr Tyrosine Kinase Inhibitors ◽  
Synthesis And Biological Evaluation

Biomass-involved synthesis of N-substituted benzofuro[2,3-d]pyrimidine-4-amines and biological evaluation as novel EGFR tyrosine kinase inhibitors

2017 ◽  
Vol 15 (23) ◽  
pp. 4971-4977 ◽  
Author(s):  
Jianfei Sheng ◽  
Zhihong Liu ◽  
Ming Yan ◽  
Xuejing Zhang ◽  
Dejian Wang ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Shikimic Acid ◽  
Biological Evaluation ◽  
Facile Synthesis ◽  
Egfr Tyrosine Kinase ◽  
Egfr Tyrosine Kinase Inhibitors ◽  
Egfr Tkis

Facile synthesis of N-substituted benzofuro[2,3-d]pyrimidine-4-amines from shikimic acid and biological evaluation as novel EGFR TKIs is described.

Sign in / Sign up

Export Citation Format

Share Document