scholarly journals Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

2021 ◽  
pp. 116093
Author(s):  
Adrianne Wallace-Povirk ◽  
Nian Tong ◽  
Jennifer Wong-Roushar ◽  
Carrie O'Connor ◽  
Xilin Zhou ◽  
...  
Keyword(s):  
De Novo ◽  
Folate Receptor ◽  
Human Tumors ◽  
Purine Nucleotide ◽  
Nucleotide Biosynthesis ◽  
Glycinamide Ribonucleotide Formyltransferase ◽  
Dual Inhibitors ◽  
Pyrimidine Analogs

Regulation of purine nucleotide biosynthesis: in yeast and beyond

2006 ◽  
Vol 34 (5) ◽  
pp. 786-790 ◽  
Author(s):  
R.J. Rolfes
Keyword(s):  
Saccharomyces Cerevisiae ◽  
De Novo ◽  
Purine Nucleotide ◽  
De Novo Synthesis ◽  
Normal Functioning ◽  
Purine Nucleotides ◽  
Yeast Saccharomyces Cerevisiae ◽  
Nucleotide Biosynthesis ◽  
Salvage Pathways ◽  
Pool Sizes

Purine nucleotides are critically important for the normal functioning of cells due to their myriad of activities. It is important for cells to maintain a balance in the pool sizes of the adenine-containing and guanine-containing nucleotides, which occurs by a combination of de novo synthesis and salvage pathways that interconvert the purine nucleotides. This review describes the mechanism for regulation of the biosynthetic genes in the yeast Saccharomyces cerevisiae and compares this mechanism with that described in several microbial species.

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