scholarly journals Discovery of 5-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity

2013 ◽  
Vol 56 (24) ◽  
pp. 10016-10032 ◽  
Author(s):  
Shermaine Mitchell-Ryan ◽  
Yiqiang Wang ◽  
Sudhir Raghavan ◽  
Manasa Punaha Ravindra ◽  
Eric Hales ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
De Novo ◽  
Ampk Activation ◽  
Purine Nucleotide ◽  
Nucleotide Biosynthesis ◽  
Glycinamide Ribonucleotide Formyltransferase

scholarly journals Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis

2018 ◽  
Vol 61 (5) ◽  
pp. 2027-2040 ◽  
Author(s):  
Manasa Ravindra ◽  
Adrianne Wallace-Povirk ◽  
Mohammad A. Karim ◽  
Mike R. Wilson ◽  
Carrie O’Connor ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Tumor Targeting ◽  
De Novo ◽  
Folate Receptor ◽  
Purine Nucleotide ◽  
Nucleotide Biosynthesis

scholarly journals Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis

2019 ◽  
Vol 27 (23) ◽  
pp. 115125
Author(s):  
Weiguo Xiang ◽  
Aamod Dekhne ◽  
Arpit Doshi ◽  
Carrie O'Connor ◽  
Zhanjun Hou ◽  
...  
Keyword(s):  
De Novo ◽  
Folate Receptor ◽  
Purine Nucleotide ◽  
Selective Uptake ◽  
Nucleotide Biosynthesis

Regulation of purine nucleotide biosynthesis: in yeast and beyond

2006 ◽  
Vol 34 (5) ◽  
pp. 786-790 ◽  
Author(s):  
R.J. Rolfes
Keyword(s):  
Saccharomyces Cerevisiae ◽  
De Novo ◽  
Purine Nucleotide ◽  
De Novo Synthesis ◽  
Normal Functioning ◽  
Purine Nucleotides ◽  
Yeast Saccharomyces Cerevisiae ◽  
Nucleotide Biosynthesis ◽  
Salvage Pathways ◽  
Pool Sizes

Purine nucleotides are critically important for the normal functioning of cells due to their myriad of activities. It is important for cells to maintain a balance in the pool sizes of the adenine-containing and guanine-containing nucleotides, which occurs by a combination of de novo synthesis and salvage pathways that interconvert the purine nucleotides. This review describes the mechanism for regulation of the biosynthetic genes in the yeast Saccharomyces cerevisiae and compares this mechanism with that described in several microbial species.

scholarly journals Phenotypes in utilization of formate for purine nucleotide biosynthesis de novo in adult humans

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Joseph E Baggott ◽  
Gregory S Gorman ◽  
Sarah L Morgan
Keyword(s):  
De Novo ◽  
Purine Nucleotide ◽  
Nucleotide Biosynthesis ◽  
Adult Humans

Phenotypes and circadian rhythm in utilization of formate in purine nucleotide biosynthesis de novo in adult humans

Life Sciences ◽  
2011 ◽  
Vol 88 (15-16) ◽  
pp. 688-692 ◽  
Author(s):  
Joseph E. Baggott ◽  
Gregory S. Gorman ◽  
Sarah L. Morgan
Keyword(s):  
Circadian Rhythm ◽  
De Novo ◽  
Purine Nucleotide ◽  
Nucleotide Biosynthesis ◽  
Adult Humans

scholarly journals The Presence of a Limited Portion of the Pathway de Novo of Purine Nucleotide Biosynthesis in the Rabbit Erythrocyte in Vitro

1960 ◽  
Vol 235 (10) ◽  
pp. 2924-2927 ◽  
Author(s):  
Bertram A. Lowy ◽  
Marjorie K. Williams
Keyword(s):  
De Novo ◽  
Purine Nucleotide ◽  
Rabbit Erythrocyte ◽  
Nucleotide Biosynthesis
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