Design, Synthesis, and Antiviral activity of 1,2,3,4-Tetrahydropyrimidine derivatives acting as novel entry inhibitors to target at “Phe43 cavity” of HIV-1 gp120

2021 ◽  
pp. 116526
Author(s):  
Jagadeesh Senapathi ◽  
Bommakanti Akhila ◽  
Kusuma veena ◽  
Srinivas Vangara ◽  
Anand K Kondapi
Keyword(s):  
Antiviral Activity ◽  
Design Synthesis ◽  
Entry Inhibitors ◽  
Hiv 1

scholarly journals Design, Synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors

2021 ◽  
pp. 116000
Author(s):  
Francesca Curreli ◽  
Shahad Ahmed ◽  
Sofia M. Benedict Victor ◽  
Ildar R. Iusupov ◽  
Evgeny A. Spiridonov ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Small Molecule ◽  
Design Synthesis ◽  
Entry Inhibitors ◽  
Hiv 1

scholarly journals Design, Synthesis, and Antiviral Activity of Entry Inhibitors That Target the CD4-Binding Site of HIV-1

2012 ◽  
Vol 55 (10) ◽  
pp. 4764-4775 ◽  
Author(s):  
Francesca Curreli ◽  
Spreeha Choudhury ◽  
Ilya Pyatkin ◽  
Victor P. Zagorodnikov ◽  
Anna Khulianova Bulay ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Binding Site ◽  
Design Synthesis ◽  
Entry Inhibitors ◽  
Cd4 Binding Site ◽  
Hiv 1

Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors

2021 ◽  
Vol 48 ◽  
pp. 116414
Author(s):  
Jing Li ◽  
Xiangyi Jiang ◽  
Alexej Dick ◽  
Prem Prakash Sharma ◽  
Chin-Ho Chen ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Design Synthesis ◽  
Hiv 1

scholarly journals Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity

2016 ◽  
Vol 24 (22) ◽  
pp. 5988-6003 ◽  
Author(s):  
Francesca Curreli ◽  
Dmitry S. Belov ◽  
Ranjith R. Ramesh ◽  
Naisargi Patel ◽  
Andrea Altieri ◽  
...  
Keyword(s):  
Small Molecule ◽  
Broad Spectrum ◽  
Design Synthesis ◽  
Entry Inhibitors ◽  
Anti Hiv ◽  
Hiv 1

Design, Synthesis and Antiviral Activity of New Pyridinone Derivatives

1997 ◽  
Vol 8 (2) ◽  
pp. 161-172 ◽  
Author(s):  
F Jourdan ◽  
J Renault ◽  
C Fossey ◽  
R Bureau ◽  
D Ladurée ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiviral Activity ◽  
Hybrid Structure ◽  
Design Synthesis ◽  
Structural Correlation ◽  
Immunodeficiency Virus ◽  
Structural And Electronic Properties ◽  
Anti Hiv ◽  
Hiv 1

A molecular modelling study was carried out in order to compare the structural and electronic properties of the pyridinone L-696,229 and the HEPT derivative EBPU. This comparison led to a hybrid structure, 3-(benzyloxymethyl)-5-ethyl-6-methylpyridin-2-one [18a], which revealed a good structural correlation with the models. A series of 2-[(arylmethyl)oxymethyl]pyridin-2-ones related to [18a] was synthesized and tested for antiviral activity against human immunodeficiency virus type 1 (HIV-1). Compound [18a] and four other derivatives showed anti-HIV-1 activity.

scholarly journals Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

2012 ◽  
Vol 55 (9) ◽  
pp. 4382-4396 ◽  
Author(s):  
Judith M. LaLonde ◽  
Young Do Kwon ◽  
David M. Jones ◽  
Alexander W. Sun ◽  
Joel R. Courter ◽  
...  
Keyword(s):  
Small Molecule ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Entry Inhibitors ◽  
Hiv 1

scholarly journals Synthesis, Antiviral Activity, and Structure–Activity Relationship of 1,3‐Benzodioxolyl Pyrrole‐Based Entry Inhibitors Targeting the Phe43 Cavity in HIV‐1 gp120

ChemMedChem ◽  
2018 ◽  
Vol 13 (21) ◽  
pp. 2332-2348 ◽  
Author(s):  
Francesca Curreli ◽  
Dmitry S. Belov ◽  
Shahad Ahmed ◽  
Ranjith R. Ramesh ◽  
Alexander V. Kurkin ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Entry Inhibitors ◽  
Structure Activity ◽  
Relationship Of ◽  
Hiv 1
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