Design, Synthesis and Antiviral Activity of New Pyridinone Derivatives
1997 ◽
Vol 8
(2)
◽
pp. 161-172
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Keyword(s):
Anti Hiv
◽
A molecular modelling study was carried out in order to compare the structural and electronic properties of the pyridinone L-696,229 and the HEPT derivative EBPU. This comparison led to a hybrid structure, 3-(benzyloxymethyl)-5-ethyl-6-methylpyridin-2-one [18a], which revealed a good structural correlation with the models. A series of 2-[(arylmethyl)oxymethyl]pyridin-2-ones related to [18a] was synthesized and tested for antiviral activity against human immunodeficiency virus type 1 (HIV-1). Compound [18a] and four other derivatives showed anti-HIV-1 activity.
2007 ◽
Vol 51
(9)
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pp. 3147-3154
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2005 ◽
Vol 49
(10)
◽
pp. 4110-4120
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2007 ◽
Vol 51
(11)
◽
pp. 4036-4043
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1999 ◽
Vol 43
(10)
◽
pp. 2376-2382
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1999 ◽
Vol 43
(2)
◽
pp. 259-263
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1998 ◽
Vol 9
(5)
◽
pp. 412-421
◽
2003 ◽
Vol 14
(5)
◽
pp. 271-279
◽
1996 ◽
Vol 40
(6)
◽
pp. 1491-1497
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