CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.09.077 ◽

2004 ◽

Vol 14 (24) ◽

pp. 6017-6021 ◽

Author(s):

Elfatih Elzein ◽

Prabha Ibrahim ◽

Dmitry O. Koltun ◽

Ken Rehder ◽

Kevin D. Shenk ◽

...

Keyword(s):

Fatty Acid Oxidation ◽

Oral Bioavailability ◽

Acid Oxidation ◽

Oxidation Inhibitor

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CVT-4325: A Potent Fatty Acid Oxidation Inhibitor with Favorable Oral Bioavailability.

10.1002/chin.200515236 ◽

2005 ◽

Vol 36 (15) ◽

Author(s):

Jeff A. Zablocki ◽

et al. et al.

Keyword(s):

Fatty Acid Oxidation ◽

Oral Bioavailability ◽

Acid Oxidation ◽

Oxidation Inhibitor

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Ranolazine, a partial fatty acid oxidation inhibitor, improves left ventricular function in dogs with heart failure through an increase in myocardial efficiency

Journal of Molecular and Cellular Cardiology ◽

10.1016/s0022-2828(01)90629-7 ◽

2001 ◽

Vol 33 (6) ◽

pp. A164

Author(s):

M.P. Chandler ◽

W.C. Stanley ◽

H. Morita ◽

G. Suzuki ◽

O. Nass ◽

...

Keyword(s):

Heart Failure ◽

Left Ventricular Function ◽

Ventricular Function ◽

Fatty Acid Oxidation ◽

Left Ventricular ◽

Acid Oxidation ◽

Oxidation Inhibitor ◽

Myocardial Efficiency

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Oxfenicine, a partial fatty acid oxidation inhibitor results in lower myocardial FFA uptakes and lactate production during demand-induced ischemia

Journal of Molecular and Cellular Cardiology ◽

10.1016/s0022-2828(01)90649-2 ◽

2001 ◽

Vol 33 (6) ◽

pp. A169

Author(s):

H. Huang ◽

M.P. Chandler ◽

T.A. McElfresh ◽

S.S. Gadgil ◽

W.C. Stanley

Keyword(s):

Fatty Acid Oxidation ◽

Lactate Production ◽

Acid Oxidation ◽

Oxidation Inhibitor

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Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid (TDGA) on glucose and fatty acid oxidation in isolated rat soleus muscle

International Journal of Biochemistry ◽

10.1016/0020-711x(88)90479-x ◽

1988 ◽

Vol 20 (2) ◽

pp. 155-160 ◽

Author(s):

Robert W. Tuman ◽

John M. Joseph ◽

Henry J. Brentzel ◽

Gene F. Tutwiler

Keyword(s):

Fatty Acid Oxidation ◽

Soleus Muscle ◽

Acid Oxidation ◽

Oxidation Inhibitor ◽

Rat Soleus Muscle ◽

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Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats

Physiology & Behavior ◽

10.1016/j.physbeh.2004.01.007 ◽

2004 ◽

Vol 81 (1) ◽

pp. 157-162 ◽

Author(s):

Charles C Horn ◽

Hong Ji ◽

Mark I Friedman

Keyword(s):

Food Intake ◽

Fatty Acid Oxidation ◽

Acid Oxidation ◽

Energy Status ◽

Oxidation Inhibitor

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A Randomized Clinical Trial of Trimetazidine, a Partial Free Fatty Acid Oxidation Inhibitor, in Patients With Heart Failure

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2006.03.060 ◽

2006 ◽

Vol 48 (5) ◽

pp. 992-998 ◽

Author(s):

Gabriele Fragasso ◽

Altin Palloshi ◽

Patrizia Puccetti ◽

Carmen Silipigni ◽

Alessandra Rossodivita ◽

...

Keyword(s):

Heart Failure ◽

Clinical Trial ◽

Free Fatty Acid ◽

Randomized Clinical Trial ◽

Fatty Acid Oxidation ◽

Acid Oxidation ◽

Oxidation Inhibitor ◽

Patients With Heart Failure ◽

Free Fatty Acid Oxidation

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Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat

European Journal of Pharmacology ◽

10.1016/s0014-2999(01)00920-7 ◽

2001 ◽

Vol 418 (1-2) ◽

pp. 105-110 ◽

Author(s):

Kai Zacharowski ◽

Brent Blackburn ◽

Christoph Thiemermann

Keyword(s):

Infarct Size ◽

Fatty Acid Oxidation ◽

Cardiac Troponin ◽

Myocardial Infarct ◽

Acid Oxidation ◽

Cardiac Troponin T ◽

Myocardial Infarct Size ◽

Oxidation Inhibitor

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Ranolazine, partial fatty acid oxidation inhibitor improves left ventricular function in dogs with heart failure

Journal of Molecular and Cellular Cardiology ◽

10.1016/s0022-2828(02)91016-3 ◽

2002 ◽

Vol 34 (6) ◽

pp. A81

Author(s):

Margaret P. Chandler ◽

William C. Stanley ◽

Hideaki Morita ◽

George Suzuki ◽

Omar Nass ◽

...

Keyword(s):

Heart Failure ◽

Left Ventricular Function ◽

Ventricular Function ◽

Fatty Acid Oxidation ◽

Left Ventricular ◽

Acid Oxidation ◽

Oxidation Inhibitor

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A Novel Partial Fatty Acid Oxidation Inhibitor Decreases Myocardial Oxygen Consumption and Improves Cardiac Efficiency in Demand-induced Ischemic Heart

Journal of Cardiovascular Pharmacology ◽

10.1097/fjc.0b013e318166803b ◽

2008 ◽

Vol 51 (4) ◽

pp. 372-379 ◽

Author(s):

Lin Wu ◽

Luiz Belardinelli ◽

Heather Fraser

Keyword(s):

Oxygen Consumption ◽

Fatty Acid Oxidation ◽

Myocardial Oxygen Consumption ◽

Ischemic Heart ◽

Acid Oxidation ◽

Cardiac Efficiency ◽

Oxidation Inhibitor

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Ranolazine, a Partial Fatty Acid Oxidation Inhibitor, its Potential Benefit in Angina and Other Cardiovascular Disorders

Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) ◽

10.2174/157489007779606095 ◽

2007 ◽

Vol 2 (1) ◽

pp. 35-39 ◽

Author(s):

Bharti Bhandari ◽

L. Subramanian

Keyword(s):

Fatty Acid Oxidation ◽

Potential Benefit ◽

Acid Oxidation ◽

Cardiovascular Disorders ◽

Oxidation Inhibitor

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