scholarly journals A Randomized Clinical Trial of Trimetazidine, a Partial Free Fatty Acid Oxidation Inhibitor, in Patients With Heart Failure

2006 ◽  
Vol 48 (5) ◽  
pp. 992-998 ◽  
Author(s):  
Gabriele Fragasso ◽  
Altin Palloshi ◽  
Patrizia Puccetti ◽  
Carmen Silipigni ◽  
Alessandra Rossodivita ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Trial ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Randomized Clinical Trial ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Oxidation Inhibitor ◽  
Patients With Heart Failure ◽  
Free Fatty Acid Oxidation

scholarly journals Modulation of Cardiac Metabolism in Heart Failure

2019 ◽  
Vol 17 ◽  
Author(s):  
Giuseppe Rosano ◽  
Andrew Coats
Keyword(s):  
Heart Failure ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Skeletal Muscles ◽  
Cardiac Metabolism ◽  
Acid Oxidation ◽  
Patients With Heart Failure ◽  
Free Fatty Acid Oxidation ◽  
Capacity Modulation

Heart failure is associated with altered cardiac metabolism, in part, due to maladaptive mechanisms, in part secondary to comorbidities such as diabetes and ischaemic heart disease. The metabolic derangements taking place in heart failure are not limited to the cardiac myocytes, but extend to skeletal muscles and the vasculature causing changes that contribute to the worsening of exercise capacity. Modulation of cardiac metabolism with partial inhibition of free fatty acid oxidation has been shown to be beneficial in patients with heart failure. At the present, the bulk of evidence for this class of drugs comes from Trimetazidine. Newer compounds partially inhibiting free fatty acid oxidation or facilitating the electron transport on the mitochondrial cristae are in early phase of their clinical development.

New directions in the treatment of heart failure: Targeting free fatty acid oxidation

2007 ◽  
Vol 4 (4) ◽  
pp. 236-242 ◽  
Author(s):  
Gabriele Fragasso ◽  
Roberto Spoladore ◽  
Giorgio Bassanelli ◽  
Amarild Cuko ◽  
Chiara Montano ◽  
...  
Keyword(s):  
Heart Failure ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
New Directions ◽  
Free Fatty Acid Oxidation

scholarly journals Weight Reduction and the Impaired Plasma-Derived Free Fatty Acid Oxidation in Type 2 Diabetic Subjects1

2001 ◽  
Vol 86 (4) ◽  
pp. 1638-1644
Author(s):  
E. E. Blaak ◽  
B. H. R. Wolffenbuttel ◽  
W. H. M. Saris ◽  
M. M. A. L. Pelsers ◽  
A. J. M. Wagenmakers
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Weight Reduction ◽  
Acid Oxidation ◽  
Free Fatty Acid Oxidation ◽  
Type 2 Diabetic

Validation of Tracer Estimations of Plasma Free Fatty Acid Oxidation

1994 ◽  
Vol 87 (s1) ◽  
pp. 94-95
Author(s):  
LS Sidossis ◽  
AR Coggan ◽  
A Gastaldelli ◽  
RR Wolfe
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Plasma Free Fatty Acid ◽  
Acid Oxidation ◽  
Free Fatty Acid Oxidation
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