Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties

2006 ◽  
Vol 16 (4) ◽  
pp. 845-849 ◽  
Author(s):  
John A. Wendt ◽  
Hongwei Wu ◽  
Heather G. Stenmark ◽  
Mark L. Boys ◽  
Victoria L. Downs ◽  
...  
Keyword(s):  
Αvβ3 Integrin ◽  
Integrin Receptor ◽  
Receptor Antagonists ◽  
Pharmacokinetic Properties ◽  
Αvβ3 Integrin Receptor

Synthesis and biological evaluation of potent αvβ3-integrin receptor antagonists

2006 ◽  
Vol 33 (8) ◽  
pp. 953-961 ◽  
Author(s):  
Ingrid Dijkgraaf ◽  
John A.W. Kruijtzer ◽  
Cathelijne Frielink ◽  
Annemieke C. Soede ◽  
Hans W. Hilbers ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Αvβ3 Integrin ◽  
Integrin Receptor ◽  
Receptor Antagonists ◽  
Synthesis And Biological Evaluation ◽  
Αvβ3 Integrin Receptor

Solid-phase syntheses of constrained RGD scaffolds and their binding to the αvβ3 integrin receptor

2001 ◽  
Vol 42 (42) ◽  
pp. 7387-7391 ◽  
Author(s):  
Miriam Royo ◽  
Wim Van Den Nest ◽  
Montserrat del Fresno ◽  
Ariadna Frieden ◽  
Dror Yahalom ◽  
...  
Keyword(s):  
Solid Phase ◽  
Αvβ3 Integrin ◽  
Integrin Receptor ◽  
Αvβ3 Integrin Receptor
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