Design and synthesis of N-methylmaleimide indolocarbazole bearing modified 2-acetamino acid moieties as Topoisomerase I inhibitors

Synthesis of Benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile Intermediates for the Design and Synthesis of Topoisomerase I Inhibitors.

ChemInform ◽

10.1002/chin.200627163 ◽

2006 ◽

Vol 37 (27) ◽

Author(s):

Andrew Morrell ◽

Smitha Antony ◽

Glenda Kohlhagen ◽

Yves Pommier ◽

Mark Cushman

Keyword(s):

Topoisomerase I ◽

Design And Synthesis ◽

Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile intermediates for the design and synthesis of topoisomerase I inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.01.008 ◽

2006 ◽

Vol 16 (7) ◽

pp. 1846-1849 ◽

Cited By ~ 36

Author(s):

Andrew Morrell ◽

Smitha Antony ◽

Glenda Kohlhagen ◽

Yves Pommier ◽

Mark Cushman

Keyword(s):

Topoisomerase I ◽

Design And Synthesis ◽

Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: in vitro screening, molecular docking and ADME predictions

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105174 ◽

2021 ◽

pp. 105174

Author(s):

Ramakant A. Kardile ◽

Aniket P. Sarkate ◽

Avinash S. Borude ◽

Rajendra S. Mane ◽

Deepak K. Lokwani ◽

...

Keyword(s):

Molecular Docking ◽

Topoisomerase I ◽

Quinoline Derivatives ◽

In Vitro Screening ◽

Conformationally Constrained ◽

Design And Synthesis ◽

ChemInform Abstract: Advances in Indolo[2,3-a]carbazole Chemistry: Design and Synthesis of Protein Kinase C and Topoisomerase I Inhibitors

ChemInform ◽

10.1002/chin.199918300 ◽

2010 ◽

Vol 30 (18) ◽

pp. no-no ◽

Cited By ~ 1

Author(s):

Ulf Pindur ◽

Young-Shin Kim ◽

Farokh Mehrabani

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Topoisomerase I ◽

Design And Synthesis ◽

Kinase C

Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.05.012 ◽

2011 ◽

Vol 19 (14) ◽

pp. 4399-4404 ◽

Cited By ~ 11

Author(s):

Thanh Nguyen Le ◽

Su Hui Yang ◽

Daulat Bikram Khadka ◽

Hue Thi My Van ◽

Suk Hee Cho ◽

...

Keyword(s):

Molecular Modeling ◽

Topoisomerase I ◽

Design And Synthesis ◽

Discovery of Camptothecin Based Topoisomerase I Inhibitors: Identification Using an Atom Based 3D-QSAR, Pharmacophore Modeling, Virtual Screening and Molecular Docking Approach

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207319666160810154346 ◽

2016 ◽

Vol 19 (9) ◽

pp. 752-763 ◽

Cited By ~ 4

Author(s):

Sanal Dev ◽

Sunil Dhaneshwar ◽

Bijo Mathew

Keyword(s):

Molecular Docking ◽

Virtual Screening ◽

Topoisomerase I ◽

3D Qsar ◽

Pharmacophore Modeling ◽

Docking Approach

Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

Current Topics in Medicinal Chemistry ◽

10.2174/1568026614666141215152441 ◽

2015 ◽

Vol 14 (23) ◽

pp. 2722-2728 ◽

Cited By ~ 5

Author(s):

Concepcion Alonso ◽

Maria Fuertes ◽

Maria Gonzalez ◽

Alicia Rodriguez-Gascon ◽

Gloria Rubiales ◽

...

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Antiproliferative Agents ◽

Synthesis And Biological Evaluation

New Family ◽

Investigation of Isoindolo[2,1-a]quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods

Current Computer - Aided Drug Design ◽

10.2174/1573409913666170124100334 ◽

2017 ◽

Vol 13 (3) ◽

Cited By ~ 4

Author(s):

Balazs Balogh ◽

Anna Carbone ◽

Virginia Spanò ◽

Alessandra Montalbano ◽

Paola Barraja ◽

...

Keyword(s):

Molecular Modeling ◽

Topoisomerase I ◽

Modeling Methods ◽

Mode of inhibition of eukaryotic DNA topoisomerase I inhibitors.

Nippon Nōgeikagaku Kaishi ◽

10.1271/nogeikagaku1924.65.1008 ◽

1991 ◽

Vol 65 (6) ◽

pp. 1008-1010

Author(s):

Hiro-omi TAMURA ◽

Yoji IKEGAMI

Keyword(s):

Topoisomerase I ◽

Dna Topoisomerase I ◽

Dna Topoisomerase ◽

Eukaryotic Dna

Quantitative Structure-Activity Relationship Studies on Indenoisoquinoline Topoisomerase I Inhibitors as Anticancer Agents in Human Renal Cell Carcinoma Cell Line SN12C

International Journal of Molecular Sciences ◽

10.3390/ijms13056009 ◽

2012 ◽

Vol 13 (5) ◽

pp. 6009-6025 ◽

Cited By ~ 3

Author(s):

Yi Zhi ◽

Jin Yang ◽

Shengchao Tian ◽

Fang Yuan ◽

Yang Liu ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Anticancer Agents ◽

Topoisomerase I ◽

Carcinoma Cell ◽

Quantitative Structure Activity Relationship ◽

Quantitative Structure ◽

Human Renal Cell Carcinoma ◽

Renal Cell Carcinoma Cell ◽

Structure Activity