Design, synthesis, and structure–activity relationships of pyrazole derivatives as potential FabH inhibitors

2010 ◽  
Vol 20 (15) ◽  
pp. 4657-4660 ◽  
Author(s):  
Peng-Cheng Lv ◽  
Juan Sun ◽  
Yin Luo ◽  
Ying Yang ◽  
Hai-Liang Zhu
Keyword(s):  
Pyrazole Derivatives ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

Design, synthesis of tri‐substituted pyrazole derivatives as promising antimicrobial agents and investigation of structure activity relationships

2020 ◽  
Vol 57 (5) ◽  
pp. 2288-2296
Author(s):  
Guda Mallikarjuna Reddy ◽  
Jarem Raul Garcia ◽  
Gutha Yuvaraja ◽  
Munagapati Venkata Subbaiah ◽  
Jet‐Chau Wen
Keyword(s):  
Antimicrobial Agents ◽  
Pyrazole Derivatives ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Novel Acetohydrazide Pyrazole Derivatives: Design, Synthesis, Characterization and Antimicrobial Activity

2019 ◽  
Vol 31 (12) ◽  
pp. 2740-2744
Author(s):  
Anil Verma ◽  
Vinod Kumar ◽  
Ramesh Kataria ◽  
Joginder Singh
Keyword(s):  
Mass Spectrometry ◽  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Antimicrobial Activities ◽  
Pyrazole Derivatives ◽  
Reaction Conditions ◽  
Design Synthesis ◽  
Structure Activity ◽  
Electron Withdrawing Group ◽  
Sar Study

Eleven acetohydrazide linked pyrazole derivatives were designed and synthesized via condensation of acetohyadrazide with different substituted formyl pyrazole derivatives under mild reaction conditions. Synthesized compounds were characterized on the basis of IR, NMR (1H & 13C) and mass spectrometry. The antimicrobial activities of all the compounds were screened against four bacterial and two fungal strains. Among the synthesized compounds, three compounds viz. 6b, 6c and 6d were found as efficient antimicrobial agents in reference to the standard drugs viz. ciprofloxacin and amphotericin-B. Further, structure-activity relationship (SAR) study revealed that electron-withdrawing group enhances the antimicrobial potential of synthesized derivatives as compared to other groups present in the ring. Hence, among compounds 6b-c, compound 6d could be explored further against other microbes to prove its vitality.

Design, Synthesis, and Structure−Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents

2009 ◽  
Vol 52 (16) ◽  
pp. 5020-5031 ◽  
Author(s):  
Sunil K. Vooturi ◽  
Chrissy M. Cheung ◽  
Michael J. Rybak ◽  
Steven M. Firestine
Keyword(s):  
Antibacterial Agents ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure–Activity Relationships

Synthesis ◽  
2016 ◽  
Vol 48 (17) ◽  
pp. 2739-2756 ◽  
Author(s):  
Daniele Piomelli ◽  
Eleonora Diamanti ◽  
Giovanni Bottegoni ◽  
Luca Goldoni ◽  
Natalia Realini ◽  
...  
Keyword(s):  
Acid Ceramidase ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity
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