Novel second generation analogs of eribulin. Part III: Blood–brain barrier permeability and in vivo activity in a brain tumor model

2011 ◽  
Vol 21 (6) ◽  
pp. 1639-1643 ◽  
Author(s):  
Sridhar Narayan ◽  
Eric M. Carlson ◽  
Hongsheng Cheng ◽  
Krista Condon ◽  
Hong Du ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Blood Brain Barrier ◽  
Second Generation ◽  
Tumor Model ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Brain Barrier Permeability ◽  
Brain Tumor Model

scholarly journals Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeability

2021 ◽  
Author(s):  
Chiara Borsari ◽  
Erhan Keles ◽  
Andrea Treyer ◽  
Martina De Pascale ◽  
Paul Hebeisen ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Neurological Disorders ◽  
Second Generation ◽  
Mtor Inhibitor ◽  
Kinase Inhibitor ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability

Here we present the first pyrimido-pyrrolo-oxazine-based mTOR kinase inhibitor (11) predicted to penetrate the blood brain barrier (BBB). Thus, 11 has a potential in treatments of neurological disorders.

scholarly journals Dynamic in vivo imaging of cerebral blood flow and blood–brain barrier permeability

NeuroImage ◽  
2010 ◽  
Vol 49 (1) ◽  
pp. 337-344 ◽  
Author(s):  
Ofer Prager ◽  
Yoash Chassidim ◽  
Chen Klein ◽  
Haviv Levi ◽  
Ilan Shelef ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Blood Brain Barrier ◽  
In Vivo Imaging ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability
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