Efficient synthesis of 3-O-thia-cPA and preliminary analysis of its biological activity toward autotaxin

2011 ◽  
Vol 21 (14) ◽  
pp. 4180-4182 ◽  
Author(s):  
Ryo Tanaka ◽  
Masaru Kato ◽  
Takahiro Suzuki ◽  
Atsuo Nakazaki ◽  
Emi Nozaki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Preliminary Analysis ◽  
Efficient Synthesis

ChemInform Abstract: Efficient Synthesis of 3-O-Thia-cPA and Preliminary Analysis of Its Biological Activity Toward Autotaxin.

ChemInform ◽  
2011 ◽  
Vol 42 (47) ◽  
pp. no-no
Author(s):  
Ryo Tanaka ◽  
Masaru Kato ◽  
Takahiro Suzuki ◽  
Atsuo Nakazaki ◽  
Emi Nozaki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Preliminary Analysis ◽  
Efficient Synthesis

scholarly journals Synthesis and Anti-HIV Activity of Carbamates of Antiviral Agent Stavudine

2002 ◽  
Vol 13 (5) ◽  
pp. 289-297
Author(s):  
TK Venkatachalam ◽  
P Samuel ◽  
IV Kourinov ◽  
FM Uckun
Keyword(s):  
Biological Activity ◽  
Antiviral Agent ◽  
Heterocyclic Amines ◽  
Efficient Synthesis ◽  
Hiv Replication ◽  
Derivatives Of ◽  
Anti Hiv

An efficient synthesis of carbamate analogues of the NRTI compound stavudine, has been achieved in five steps starting from commercially available thymidine. The synthesis involves conversion of thymidine into stavudine followed by condensation with carbaimidazole derivative obtained from various aromatic and heterocyclic amines in dimethylformamide solvent. The analogues thus obtained were further purified by crystallization to furnish analytically pure products. Examination of biological activity of these carbamate derivatives of stavudine showed that they inhibited HIV replication only at micro-molar concentrations.

Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules

2010 ◽  
Vol 20 (14) ◽  
pp. 4147-4151 ◽  
Author(s):  
Shuk-Yan Cheng ◽  
Marcus Chun-Wah Yuen ◽  
Pik-Ling Lam ◽  
Roberto Gambari ◽  
Raymond Siu-Ming Wong ◽  
...  
Keyword(s):  
Biological Activity ◽  
Preliminary Analysis

scholarly journals Efficient Synthesis and X-ray Structure of [1,2,4]Triazolo[4,3-a]pyriaadines via Oxidative Cyclization Using N-Chlorosuccinimide (NCS)

Crystals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1156
Author(s):  
Said El-Kurdi ◽  
Bassam Abu Thaher ◽  
Kanan Wahedy ◽  
Dieter Schollmeyer ◽  
Levin Nopper ◽  
...  
Keyword(s):  
Biological Activity ◽  
Oxidative Cyclization ◽  
Monoclinic Space Group ◽  
Efficient Synthesis ◽  
X Ray Diffraction ◽  
Space Group ◽  
X Ray ◽  
Mild Conditions ◽  
Pharmaceutical Applications

Triazolopyridines are a family of compounds that, owing to their biological activity, have many pharmaceutical applications. In this study, 3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine and 6-bromo-3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine were synthesized by using the chlorinated agent NCS for hydrazones under very mild conditions. The characterization of these compounds was achieved by 1H NMR, 13C NMR, FTIR, MS and X-ray diffraction. The compound 3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine was crystallized in the monoclinic space group P 21/c with a = 15.1413(12), b = 6.9179(4), c = 13.0938(8) Å, β = 105.102(6)°, V = 1324.16(16)Å3, Z = 4, and R = 0.0337. Also compound 6-bromo-3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine was crystallized in the monoclinic space group P 21/c with a = 14.3213(11), b = 6.9452(4) (4), c = 12.6860(8)Å, β = 100.265(6)°, V = 1241.62(14)Å3, Z = 4, and R = 0.0561.

An efficient synthesis and biological activity of substituted p-benzoquinones

2006 ◽  
Vol 14 (24) ◽  
pp. 8519-8526 ◽  
Author(s):  
Manoj Batra ◽  
Prashant Kriplani ◽  
Chhavi Batra ◽  
K.G. Ojha
Keyword(s):  
Biological Activity ◽  
Efficient Synthesis

Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents

2015 ◽  
Vol 96 ◽  
pp. 218-230 ◽  
Author(s):  
Suckchang Hong ◽  
Yoonho Shin ◽  
Myunggi Jung ◽  
Min Woo Ha ◽  
Yohan Park ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Efficient Synthesis ◽  
Psammaplin A
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