In vitro activity of salicylamide derivatives against vancomycin-resistant enterococci

2018 ◽  
Vol 28 (12) ◽  
pp. 2184-2188 ◽  
Author(s):  
Sarka Pospisilova ◽  
Hana Michnova ◽  
Tereza Kauerova ◽  
Karel Pauk ◽  
Peter Kollar ◽  
...  
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Vancomycin Resistant Enterococci ◽  
Salicylamide Derivatives ◽  
Vancomycin Resistant

scholarly journals In Vitro Activity and Killing Effect of Uperin 3.6 against Gram-Positive Cocci Isolated from Immunocompromised Patients

2005 ◽  
Vol 49 (9) ◽  
pp. 3933-3936 ◽  
Author(s):  
Andrea Giacometti ◽  
Oscar Cirioni ◽  
Wojciech Kamysz ◽  
Carmela Silvestri ◽  
Alberto Licci ◽  
...  
Keyword(s):  
Vitro Activity ◽  
Immunocompromised Patients ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Killing Effect ◽  
Methicillin Resistant ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant ◽  
Gram Positive Cocci

ABSTRACT The in vitro activity of uperin 3.6, alone or combined with six antibiotics, against gram-positive cocci, including Rhodococcus equi, methicillin-resistant staphylococci, and vancomycin-resistant enterococci, was investigated. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when uperin 3.6 was combined with clarithromycin and doxycycline.

The Comparative in vitro Activity of Clinafloxacin and Other Antimicrobials against Vancomycin-Susceptible and Vancomycin-Resistant Enterococci

Chemotherapy ◽  
1996 ◽  
Vol 42 (4) ◽  
pp. 235-239 ◽  
Author(s):  
Gail S. Itokazu ◽  
Catherine Nathan ◽  
Radhika Hariharan ◽  
Jay R. Kostman ◽  
Sherwin A. Kabins ◽  
...  
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

scholarly journals In Vitro Activity of Telavancin against Gram-Positive Clinical Isolates Recently Obtained in Europe

2007 ◽  
Vol 51 (9) ◽  
pp. 3420-3424 ◽  
Author(s):  
W. T. M. Jansen ◽  
A. Verel ◽  
J. Verhoef ◽  
D. Milatovic
Keyword(s):  
Streptococcus Pneumoniae ◽  
Methicillin Resistance ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Viridans Streptococci ◽  
Gram Positive ◽  
Vancomycin Resistant Enterococci ◽  
Group A ◽  
Vancomycin Resistant

ABSTRACT The in vitro activity of telavancin was tested against 620 gram-positive isolates. For staphylococci, MICs at which 50 and 90% of isolates were inhibited (MIC50 and MIC90) were both 0.25 μg/ml, irrespective of methicillin resistance. MIC50 and MIC90 were 0.25 and 0.5 μg/ml for vancomycin-susceptible enterococci and 1 and 2 μg/ml for vancomycin-resistant enterococci, respectively. Streptococcus pneumoniae, group A and B beta-hemolytic streptococci, and viridans streptococci were inhibited by ≤0.12 μg/ml.

scholarly journals Impact of Human Serum Albumin on Oritavancin In Vitro Activity against Enterococci

2009 ◽  
Vol 53 (6) ◽  
pp. 2687-2689 ◽  
Author(s):  
Geoffrey A. McKay ◽  
Sylvain Beaulieu ◽  
Ingrid Sarmiento ◽  
Francis F. Arhin ◽  
Thomas R. Parr ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant ◽  
Time Kill ◽  
The Impact

ABSTRACT Oritavancin is a lipoglycopeptide with activity against gram-positive pathogens including vancomycin-resistant enterococci. The impact of human serum albumin (HSA) on oritavancin activity against enterococci was compared to those of vancomycin, daptomycin, teicoplanin, and linezolid in vitro using MIC and time-kill methods. Oritavancin MICs increased between 0- and 8-fold in the presence of HSA. In time-kill assays with HSA, oritavancin retained activity, killing or inhibiting enterococci more rapidly than did comparators when peak concentrations were simulated.

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