Discovery of hydroxy pyrimidine Factor IXa inhibitors

2020 ◽  
Vol 30 (15) ◽  
pp. 127279
Author(s):  
Charles L. Jayne ◽  
Teresa Andreani ◽  
Tin-Yau Chan ◽  
Mariappan V. Chelliah ◽  
Martin C. Clasby ◽  
...  
Keyword(s):  
Factor Ixa

The Effect of Antithrombin III on the Activity of the Coagulation Factors VII, IX and X

1976 ◽  
Vol 35 (02) ◽  
pp. 295-304 ◽  
Author(s):  
B Østerud ◽  
M Miller-Andersson ◽  
U Abildgaard ◽  
H Prydz
Keyword(s):  
Antithrombin Iii ◽  
Factor Xa ◽  
Coagulation Factors ◽  
Disc Electrophoresis ◽  
Polyacrylamide Gel ◽  
Factor Vii ◽  
Native Form ◽  
Factor Ixa ◽  
Plasma Factor

SummaryAntithrombin III, purified to homogeneity according to Polyacrylamide gel disc electrophoresis and immunoelectrophoresis, inhibited the activity of purified factor IXa and Xa, whereas factor VII was not inhibited either in the active or in the native form.Antithrombin III is the single most important inhibitor of factor Xa in plasma. Factor Xa does not, however, reduce the activity of antithrombin III against thrombin.

In Vitro Thrombogenicity Tests of Factor IX Concentrates

1979 ◽  
Vol 42 (05) ◽  
pp. 1355-1367 ◽  
Author(s):  
C V Prowse ◽  
A Chirnside ◽  
R A Elton
Keyword(s):  
Factor Viii ◽  
Partial Thromboplastin Time ◽  
Generation Time ◽  
Activated Partial Thromboplastin Time ◽  
Factor Ix ◽  
In Vitro Tests ◽  
Factor Viii Inhibitor ◽  
Factor Ixa ◽  
Viii Inhibitor

SummaryVarious factor IX concentrates have been examined in a number of in vitro tests of thrombogenicity. The results suggest that some tests are superfluous as in concentrates with activity in any of these tests activation is revealed by a combination of the non-activated partial thromboplastin time, the thrombin (or Xa) generation time and factor VIII inhibitor bypassing activity tests. Assay of individual coagulant enzymes revealed that most concentrates contained more factor IXa than Xa. However only a small number of concentrates, chiefly those that had been purposefully activated, contained appreciable amounts of either enzyme.

Activation of Human Coagulation Factor VIII by Activated Factor X, the Common Product of the Intrinsic and the Extrinsic Pathway of Blood Coagulation

1982 ◽  
Vol 47 (02) ◽  
pp. 096-100 ◽  
Author(s):  
K Mertens ◽  
R M Bertina
Keyword(s):  
Factor Viii ◽  
Human Factor ◽  
Intrinsic Factor ◽  
Factor Xa ◽  
Coagulation Factor ◽  
Factor X ◽  
Extrinsic Factor ◽  
Extrinsic Pathway ◽  
Factor Ixa ◽  
The Common

SummaryThe intrinsic activation of human factor X has been studied in a system consisting of purified factors and in plasma. In both these systems factor Xa stimulated the activation of factor X by factor IXa plus factor VIII This is due to the activation of factor VIII by factor Xa. When this factor Xa is formed via the extrinsic pathway, the extrinsic factor X activator functions as a stimulator of the intrinsic factor X activator.

scholarly journals Comparative platelet binding and kinetic studies with normal and variant factor IXa molecules.

1990 ◽  
Vol 265 (34) ◽  
pp. 20907-20911
Author(s):  
S S Ahmad ◽  
R Rawala-Sheikh ◽  
D M Monroe ◽  
H R Roberts ◽  
P N Walsh
Keyword(s):  
Kinetic Studies ◽  
Factor Ixa ◽  
Platelet Binding

scholarly journals Soluble Phosphatidylserine Binds to Two Sites on Human Factor IXa in a Ca2+ Dependent Fashion to Specifically Regulate Structure and Activity

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100006 ◽  
Author(s):  
Rinku Majumder ◽  
Tilen Koklic ◽  
Tanusree Sengupta ◽  
Daud Cole ◽  
Rima Chattopadhyay ◽  
...  
Keyword(s):  
Human Factor ◽  
Factor Ixa ◽  
Structure And Activity

scholarly journals Factor IXa Inhibitors as Novel Anticoagulants

2007 ◽  
Vol 27 (4) ◽  
pp. 722-727 ◽  
Author(s):  
Emily L. Howard ◽  
Kristian C.D. Becker ◽  
Christopher P. Rusconi ◽  
Richard C. Becker
Keyword(s):  
Novel Anticoagulants ◽  
Factor Ixa
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