Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy

Cathepsin C ◽

Synthesis of 3,7-Anhydro-d-glycero-d-ido-octitol 1,5,6-Trisphosphate as an IP3Receptor Ligand Using a Radical Cyclization Reaction with a Vinylsilyl Tether as the Key Step. Conformational Restriction Strategy Using Steric Repulsion between Adjacent Bulky Protecting Groups on a Pyranose Ring

The Journal of Organic Chemistry ◽

10.1021/jo0002339 ◽

2000 ◽

Vol 65 (18) ◽

pp. 5547-5557 ◽

Cited By ~ 35

Author(s):

Satoshi Shuto ◽

Yumi Yahiro ◽

Satoshi Ichikawa ◽

Akira Matsuda

Keyword(s):

Radical Cyclization ◽

Cyclization Reaction ◽

Protecting Groups ◽

Steric Repulsion ◽

Pyranose Ring ◽

Generation of tricyclic imidazo[1,2- a ]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2017.03.090 ◽

2017 ◽

Vol 27 (11) ◽

pp. 2536-2543 ◽

Cited By ~ 8

Author(s):

Sonia Martínez González ◽

Sonsoles Rodríguez-Arístegui ◽

Ana Isabel Hernández ◽

Carmen Varela ◽

Esther González Cantalapiedra ◽

...

Keyword(s):

Pi3k Inhibitors ◽

An Efficient Synthesis of β-C-Glycosides Based on the Conformational Restriction Strategy: Lewis Acid Promoted Silane Reduction of the Anomeric Position with Complete Stereoselectivity

Organic Letters ◽

10.1021/ol048525+ ◽

2004 ◽

Vol 6 (21) ◽

pp. 3751-3754 ◽

Cited By ~ 40

Author(s):

Masaru Terauchi ◽

Hiroshi Abe ◽

Akira Matsuda ◽

Satoshi Shuto

Keyword(s):

Lewis Acid ◽

Efficient Synthesis ◽

Faculty Opinions recommendation of Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1046519.496492 ◽

2006 ◽

Author(s):

Andrew Combs

Keyword(s):

Strategy Development ◽

Receptor Antagonists ◽

Restriction Strategy ◽

H4 Receptor ◽

Histamine H3

A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b00972 ◽

2019 ◽

Vol 62 (18) ◽

pp. 8609-8630 ◽

Cited By ~ 5

Author(s):

Chiara Borsari ◽

Denise Rageot ◽

Alix Dall’Asen ◽

Thomas Bohnacker ◽

Anna Melone ◽

...

Keyword(s):

Mtor Inhibitor ◽

Efficient synthesis of β-C-glucosides via radical cyclization with a silicon tether based on the conformational restriction strategy

Tetrahedron Letters ◽

10.1016/j.tetlet.2005.07.087 ◽

2005 ◽

Vol 46 (38) ◽

pp. 6555-6558 ◽

Cited By ~ 7

Author(s):

Masaru Terauchi ◽

Akira Matsuda ◽

Satoshi Shuto

Keyword(s):

Radical Cyclization ◽

Efficient Synthesis ◽

Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: Histamine H3and/or H4receptor ligands with the 2,3-methanobutane backbone

Organic & Biomolecular Chemistry ◽

10.1039/c1ob06496g ◽

2012 ◽

Vol 10 (4) ◽

pp. 736-745 ◽

Cited By ~ 11

Author(s):

Mizuki Watanabe ◽

Takaaki Kobayashi ◽

Takatsugu Hirokawa ◽

Akira Yoshida ◽

Yoshihiko Ito ◽

...

Keyword(s):

Synthesis of 4,8-anhydro-d-glycero-d-ido-nonanitol 1,6,7-trisphosphate as a novel IP3 receptor ligand using a stereoselective radical cyclization reaction based on a conformational restriction strategy

Tetrahedron ◽

10.1016/j.tet.2005.02.025 ◽

2005 ◽

Vol 61 (15) ◽

pp. 3697-3707 ◽

Cited By ~ 12

Author(s):

Masaru Terauchi ◽

Yumi Yahiro ◽

Hiroshi Abe ◽

Satoshi Ichikawa ◽

Stephen C. Tovey ◽

...

Keyword(s):

Radical Cyclization ◽

Cyclization Reaction ◽

Ip3 Receptor ◽

Receptor Ligand ◽

The First Synthesis of Herbicidin B. Stereoselective Construction of the Tricyclic Undecose Moiety by a Conformational Restriction Strategy Using Steric Repulsion between Adjacent Bulky Silyl Protecting Groups on a Pyranose Ring†

Journal of the American Chemical Society ◽

10.1021/ja992608h ◽

1999 ◽

Vol 121 (44) ◽

pp. 10270-10280 ◽

Cited By ~ 58

Author(s):

Satoshi Ichikawa ◽

Satoshi Shuto ◽

Akira Matsuda

Keyword(s):

Protecting Groups ◽

Steric Repulsion ◽

Pyranose Ring ◽

An Efficient Synthesis of β-C-Glycosides Based on the Conformational Restriction Strategy: Lewis Acid Promoted Silane Reduction of the Anomeric Position with Complete Stereoselectivity

Organic Letters ◽

10.1021/ol902811y ◽

2010 ◽

Vol 12 (2) ◽

pp. 400-400 ◽

Cited By ~ 1

Author(s):

Masaru Terauchi ◽

Hiroshi Abe ◽

Akira Matsuda ◽

Satoshi Shuto

Keyword(s):

Lewis Acid ◽

Efficient Synthesis ◽