Novel Hydrazone derivatives of N-Amino-11-Azaartemisinin with High Order of Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii nigeriensis in Swiss Mice via intramuscular route

2021 ◽  
pp. 128522
Author(s):  
Manvika Karnatak ◽  
Mohammad Hassam ◽  
Ajit Shankar Singh ◽  
Dinesh Kumar Yadav ◽  
Chandan Singh ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Multidrug Resistant ◽  
Plasmodium Yoelii ◽  
High Order ◽  
Intramuscular Route ◽  
Swiss Mice ◽  
Derivatives Of

scholarly journals Sontochin as a Guide to the Development of Drugs against Chloroquine-Resistant Malaria

2012 ◽  
Vol 56 (7) ◽  
pp. 3475-3480 ◽  
Author(s):  
Sovitj Pou ◽  
Rolf W. Winter ◽  
Aaron Nilsen ◽  
Jane Xu Kelly ◽  
Yuexin Li ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Plasmodium Yoelii ◽  
Significant Activity ◽  
Drug Resistant ◽  
Content Type ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Derivatives Of

ABSTRACTSontochin was the original chloroquine replacement drug, arising from research by Hans Andersag 2 years after chloroquine (known as “resochin” at the time) had been shelved due to the mistaken perception that it was too toxic for human use. We were surprised to find that sontochin, i.e., 3-methyl-chloroquine, retains significant activity against chloroquine-resistant strains ofPlasmodium falciparum in vitro. We prepared derivatives of sontochin, “pharmachins,” with alkyl or aryl substituents at the 3 position and with alterations to the 4-position side chain to enhance activity against drug-resistant strains. Modified with an aryl substituent in the 3 position of the 7-chloro-quinoline ring, Pharmachin 203 (PH-203) exhibits low-nanomolar 50% inhibitory concentrations (IC50s) against drug-sensitive and multidrug-resistant strains andin vivoefficacy against patent infections ofPlasmodium yoeliiin mice that is superior to chloroquine. Our findings suggest that novel 3-position aryl pharmachin derivatives have the potential for use in treating drug resistant malaria.

Plasmodium yoelii nigeriensis (MDR)—Efficacy of Oral Pyronaridine against Multidrug-Resistant Malaria in Swiss Mice

2000 ◽  
Vol 94 (3) ◽  
pp. 190-193 ◽  
Author(s):  
Renu Tripathi ◽  
Aseem Umesh ◽  
Meenu Mishra ◽  
S.K. Puri ◽  
G.P. Dutta
Keyword(s):  
Multidrug Resistant ◽  
Plasmodium Yoelii ◽  
Swiss Mice

Synthesis and antimalarial activity of novel bicyclic and tricyclic aza-peroxides

RSC Advances ◽  
2016 ◽  
Vol 6 (28) ◽  
pp. 23718-23725 ◽  
Author(s):  
Lalit Yadav ◽  
Mohit K. Tiwari ◽  
Bharti Rajesh Kumar Shyamlal ◽  
Manas Mathur ◽  
Ajit K. Swami ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antimalarial Activity ◽  
Oral Route ◽  
Plasmodium Yoelii ◽  
Swiss Mice

Bicyclic and tricyclic aza-peroxides were synthesized and assessed for theirin vitroandin vivoantimalarial activities againstPlasmodium falciparum(3D7 strain) andPlasmodium yoelii nigeriensisin Swiss mice by an oral route, respectively.

6-(4′-Aryloxy-phenyl)vinyl-1,2,4-trioxanes: A new series of orally active peroxides effective against multidrug-resistant Plasmodium yoelii in Swiss mice

2010 ◽  
Vol 20 (15) ◽  
pp. 4459-4463 ◽  
Author(s):  
Chandan Singh ◽  
Ved Prakash Verma ◽  
Niraj Krishna Naikade ◽  
Ajit Shankar Singh ◽  
Mohammad Hassam ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Plasmodium Yoelii ◽  
Swiss Mice ◽  
Orally Active ◽  
Phenyl Vinyl

Poly ICLC Enhances the Antimalarial Activity of Chloroquine Against Multidrug-Resistant Plasmodium yoelii nigeriensis in Mice

1997 ◽  
Vol 17 (7) ◽  
pp. 419-423 ◽  
Author(s):  
A AWASTHI ◽  
S. MEHROTRA ◽  
V. BHAKUNI ◽  
G.P. DUTTA ◽  
H.B. LEVY ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Multidrug Resistant ◽  
Plasmodium Yoelii

Synthesis and In Vivo Antimalarial Activity of Novel Derivatives of 6- Mercaptopurine

2013 ◽  
Vol 10 (8) ◽  
pp. 741-747 ◽  
Author(s):  
Roberta Soares ◽  
Roberta Corrales ◽  
Fernanda Lopes ◽  
Marcio Alves ◽  
Adilson Silva ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Derivatives Of
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