Sclerostin antibody increases trabecular bone and bone mechanical properties by increasing osteoblast activity damaged by whole-body irradiation in mice

Bone ◽  
2021 ◽  
pp. 115918
Author(s):  
Samantha Costa ◽  
Heather Fairfield ◽  
Mariah Farrell ◽  
Connor Murphy ◽  
Ashley Soucy ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Trabecular Bone ◽  
Whole Body ◽  
Bone Mechanical Properties ◽  
Osteoblast Activity ◽  
Sclerostin Antibody

scholarly journals Influence of Orthogonal Overload on Human Vertebral Trabecular Bone Mechanical Properties

2007 ◽  
Vol 22 (11) ◽  
pp. 1690-1699 ◽  
Author(s):  
Arash Badiei ◽  
Murk J Bottema ◽  
Nicola L Fazzalari
Keyword(s):  
Mechanical Properties ◽  
Trabecular Bone ◽  
Bone Mechanical Properties ◽  
Vertebral Trabecular Bone

Predicting regional variations in trabecular bone mechanical properties within the human proximal tibia using MR imaging

Bone ◽  
2008 ◽  
Vol 43 (6) ◽  
pp. 1039-1046 ◽  
Author(s):  
Sarah L. Lancianese ◽  
Edmund Kwok ◽  
Christopher A. Beck ◽  
Amy L. Lerner
Keyword(s):  
Mechanical Properties ◽  
Mr Imaging ◽  
Trabecular Bone ◽  
Proximal Tibia ◽  
Regional Variations ◽  
Bone Mechanical Properties

scholarly journals Vertebral trabecular bone mechanical properties vary among functional groups of cetaceans

2022 ◽  
Author(s):  
D N Ingle ◽  
M E Porter
Keyword(s):  
Mechanical Properties ◽  
Yield Strength ◽  
Trabecular Bone ◽  
Functional Groups ◽  
Vertebral Column ◽  
Bone Mechanical Properties ◽  
Terrestrial Mammals ◽  
Vertebral Trabecular Bone ◽  
Deep Diving ◽  
Apparent Stiffness

Abstract Since their appearance in the fossil record 34 Mya, modern cetaceans (dolphins, whales, and porpoises) have radiated into diverse habitats circumglobally, developing vast phenotypic variations among species. Traits such as skeletal morphology and ecologically-linked behaviors denote swimming activity; trade-offs in flexibility and rigidity along the vertebral column determine patterns of caudal oscillation. Here, we categorized 10 species of cetaceans (Families Delphinidae and Kogiidae; N = 21 animals) into functional groups based on vertebral centra morphology, swimming speeds, diving behavior, and inferred swimming patterns. We quantified trabecular bone mechanical properties (yield strength, apparent stiffness, and resilience) among functional groups and regions of the vertebral column (thoracic, lumbar, and caudal). We extracted 6 mm3 samples from vertebral bodies and tested them in compression in three orientations (rostrocaudal, dorsoventral, and mediolateral) at 2 mm min−1. Overall, bone from the pre-fluke/fluke boundary had the greatest yield strength and resilience, indicating that the greatest forces are translated to the tail during caudal oscillatory swimming. Group 1, composed of five shallow-diving delphinid species, had the greatest vertebral trabecular bone yield strength, apparent stiffness, and resilience of all functional groups. Conversely, Group 3, composed of two deep-diving kogiid species, had the least strong, stiff, and resilient bone, while Group 2 (three deep-diving delphinid species) exhibited intermediate values. These data suggest that species that incorporate prolonged glides during deep descents in the water column actively swim less, and place relatively smaller loads on their vertebral columns, compared with species that execute shallower dives. We found that cetacean vertebral trabecular bone properties differed from the properties of terrestrial mammals; for every given bone strength, cetacean bone was less stiff by comparison. This relative lack of material rigidity within vertebral bone may be attributed to the non-weight bearing locomotor modes of fully aquatic mammals.

scholarly journals Heritability of lumbar trabecular bone mechanical properties in baboons

Bone ◽  
2010 ◽  
Vol 46 (3) ◽  
pp. 835-840 ◽  
Author(s):  
L.M. Havill ◽  
M.R. Allen ◽  
T.L. Bredbenner ◽  
D.B. Burr ◽  
D.P. Nicolella ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Trabecular Bone ◽  
Bone Mechanical Properties

Age-related deterioration in trabecular bone mechanical properties at material level: Nanoindentation study of the femoral neck in women by using AFM

2012 ◽  
Vol 47 (2) ◽  
pp. 154-159 ◽  
Author(s):  
Petar Milovanovic ◽  
Jelena Potocnik ◽  
Danijela Djonic ◽  
Slobodan Nikolic ◽  
Vladimir Zivkovic ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Femoral Neck ◽  
Trabecular Bone ◽  
Bone Mechanical Properties ◽  
Age Related
Sign in / Sign up

Export Citation Format

Share Document