scholarly journals The Cardiac Ryanodine Receptor N-Terminal Region Contains an Anion Binding Site that Is Targeted by Disease Mutations

Structure ◽  
2013 ◽  
Vol 21 (8) ◽  
pp. 1440-1449 ◽  
Author(s):  
Lynn Kimlicka ◽  
Ching-Chieh Tung ◽  
Anna-Carin Cecilia Carlsson ◽  
Paolo Antonio Lobo ◽  
Zhiguang Yuchi ◽  
...  
Keyword(s):  
Binding Site ◽  
Ryanodine Receptor ◽  
Terminal Region ◽  
Anion Binding ◽  
Disease Mutations ◽  
Cardiac Ryanodine Receptor

scholarly journals Crystal Structure of Cardiac Ryanodine Receptor N-Terminal Region Contains Unique Anion Binding Site Targeted by Disease-Associated Mutations

2014 ◽  
Vol 106 (2) ◽  
pp. 108a
Author(s):  
Lynn Kimlicka ◽  
Ching-Chieh Tung ◽  
Anna-Carin C. Carlsson ◽  
Paolo A. Lobo ◽  
Zhiguang Yuchi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Ryanodine Receptor ◽  
Terminal Region ◽  
Anion Binding ◽  
Cardiac Ryanodine Receptor

Human Cardiac Ryanodine Receptor: Preparation, Crystallization and Preliminary X-ray Analysis of the N-terminal Region

2013 ◽  
Vol 20 (11) ◽  
pp. 1211-1216 ◽  
Author(s):  
L’ubomír Borko ◽  
Július Kostan ◽  
Alexandra Zahradníkova ◽  
Vladimír Pevala ◽  
Juraj Gasperík ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
Terminal Region ◽  
X Ray ◽  
Cardiac Ryanodine Receptor

scholarly journals Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130606 ◽  
Author(s):  
Takashi Murayama ◽  
Nagomi Kurebayashi ◽  
Toshiko Yamazawa ◽  
Hideto Oyamada ◽  
Junji Suzuki ◽  
...  
Keyword(s):  
Malignant Hyperthermia ◽  
Ryanodine Receptor ◽  
Terminal Region ◽  
Central Core ◽  
Central Core Disease ◽  
Amino Terminal ◽  
Disease Mutations

scholarly journals Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

2021 ◽  
pp. 101412
Author(s):  
Jingyan Zhang ◽  
Daniel P. Singh ◽  
Christopher Y. Ko ◽  
Roman Nikolaienko ◽  
Siobhan M. Wong King Yuen ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
High Throughput ◽  
High Throughput Screening ◽  
Terminal Region ◽  
Cardiac Ryanodine Receptor

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor

2012 ◽  
Vol 83 (11) ◽  
pp. 1523-1529 ◽  
Author(s):  
Dan Liu ◽  
Ruwani Hewawasam ◽  
Yamuna Karunasekara ◽  
Marco G. Casarotto ◽  
Angela F. Dulhunty ◽  
...  
Keyword(s):  
Binding Site ◽  
Ryanodine Receptor ◽  
Glutathione Transferase ◽  
Divergent Region ◽  
Cardiac Ryanodine Receptor

Role of Cys3602 in the function and regulation of the cardiac ryanodine receptor

2015 ◽  
Vol 467 (1) ◽  
pp. 177-190 ◽  
Author(s):  
Tao Mi ◽  
Zhichao Xiao ◽  
Wenting Guo ◽  
Yijun Tang ◽  
Florian Hiess ◽  
...  
Keyword(s):  
Binding Site ◽  
Ryanodine Receptor ◽  
Central Region ◽  
Calcium Release ◽  
Important Determinant ◽  
Cardiac Ryanodine Receptor

Cys3602 in cardiac ryanodine receptor (RyR) mediates the action of the thiol agent N-ethylmaleimide, but not 4,4′-dithiodipyridine (DTDP). A central region encompassing the calmodulin (CaM)-binding site and Cys3602 in cardiac RyR represents an important determinant of calcium-release activation and termination.

scholarly journals Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Lynn Kimlicka ◽  
Kelvin Lau ◽  
Ching-Chieh Tung ◽  
Filip Van Petegem
Keyword(s):  
Ryanodine Receptor ◽  
Terminal Region ◽  
Disease Mutations
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