scholarly journals Investigating the Effect of Proline Linkers on Hybrid Antimicrobial Peptide Structure and Activity

2021 ◽  
Vol 120 (3) ◽  
pp. 143a
Author(s):  
Hannah Klim ◽  
Michelle Shui ◽  
Louise E. Darling ◽  
Donald E. Elmore
Keyword(s):  
Antimicrobial Peptide ◽  
Peptide Structure ◽  
Structure And Activity

scholarly journals Importance of Residue 13 and the C-Terminus for the Structure and Activity of the Antimicrobial Peptide Aurein 2.2

2010 ◽  
Vol 99 (9) ◽  
pp. 2926-2935 ◽  
Author(s):  
John T.J. Cheng ◽  
John D. Hale ◽  
Jason Kindrachuk ◽  
Havard Jessen ◽  
Melissa Elliott ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
C Terminus ◽  
Structure And Activity

scholarly journals Surveying the sequence diversity of model prebiotic peptides by mass spectrometry

2017 ◽  
Vol 114 (37) ◽  
pp. E7652-E7659 ◽  
Author(s):  
Jay G. Forsythe ◽  
Anton S. Petrov ◽  
W. Calvin Millar ◽  
Sheng-Sheng Yu ◽  
Ramanarayanan Krishnamurthy ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
De Novo ◽  
Origins Of Life ◽  
Peptide Structure ◽  
Reaction Sequence ◽  
Modern Biology ◽  
Primary Determinant ◽  
Modern Mass ◽  
Prebiotic Peptides ◽  
Structure And Activity

The rise of peptides with secondary structures and functions would have been a key step in the chemical evolution which led to life. As with modern biology, amino acid sequence would have been a primary determinant of peptide structure and activity in an origins-of-life scenario. It is a commonly held hypothesis that unique functional sequences would have emerged from a diverse soup of proto-peptides, yet there is a lack of experimental data in support of this. Whereas the majority of studies in the field focus on peptides containing only one or two types of amino acids, here we used modern mass spectrometry (MS)-based techniques to separate and sequence de novo proto-peptides containing broader combinations of prebiotically plausible monomers. Using a dry–wet environmental cycling protocol, hundreds of proto-peptide sequences were formed over a mere 4 d of reaction. Sequence homology diagrams were constructed to compare experimental and theoretical sequence spaces of tetrameric proto-peptides. MS-based analyses such as this will be increasingly necessary as origins-of-life researchers move toward systems-level investigations of prebiotic chemistry.

Spatial Structure and Activity Mechanism of a Novel Spider Antimicrobial Peptide†,‡

Biochemistry ◽  
2006 ◽  
Vol 45 (35) ◽  
pp. 10759-10767 ◽  
Author(s):  
Peter V. Dubovskii ◽  
Pavel E. Volynsky ◽  
Anton A. Polyansky ◽  
Vladimir V. Chupin ◽  
Roman G. Efremov ◽  
...  
Keyword(s):  
Spatial Structure ◽  
Antimicrobial Peptide ◽  
Activity Mechanism ◽  
Structure And Activity

scholarly journals Understanding the Importance of Residue 13 and the C-terminus on the Structure and Activity of the Amphibian Antimicrobial Peptide, Aurein 2.2

2010 ◽  
Vol 98 (3) ◽  
pp. 83a
Author(s):  
John T.J. Cheng ◽  
John D. Hale ◽  
Havard Jessen ◽  
Melissa Elliot ◽  
Robert E.W. Hancock ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
C Terminus ◽  
Structure And Activity

Correlative transmission and high-resolution scanning electron microscopic studies on pituitary cells

1990 ◽  
Vol 48 (3) ◽  
pp. 20-21
Author(s):  
S. Tai
Keyword(s):  
Cell Types ◽  
Depth Of Field ◽  
Secretory Cells ◽  
Specific Cell ◽  
Pituitary Cells ◽  
Electron Microscopic ◽  
3 Dimensional ◽  
Microscopic Studies ◽  
Structure And Activity ◽  
Intracellular Structure

Extensive cytological and histological research, correlated with physiological experimental analysis, have been done on the anterior pituitaries of many different vertebrates which have provided the knowledge to create the concept that specific cell types synthesize, store and release their specific hormones. These hormones are stored in or associated with granules. Nevertheless, there are still many doubts - that need further studies, specially on the ultrastructure and physiology of these endocrine cells during the process of synthesis, transport and secretion, whereas some new methods may provide the information about the intracellular structure and activity in detail.In the present work, ultrastructural study of the hormone-secretory cells of chicken pituitaries have been done by using TEM as well as HR-SEM, to correlate the informations obtained from 2-dimensional TEM micrography with the 3-dimensional SEM topographic images, which have a continous surface with larger depth of field that - offers the adventage to interpretate some intracellular structures which were not possible to see using TEM.

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