Intrinsic Functional Connectomes Characterize Neuroticism in Major Depressive Disorder and Predict Antidepressant Treatment Outcomes

Abstract Background Major depressive disorder (MDD) is associated with increased allostatic load (AL; a measure of physiological costs of repeated/chronic stress-responding) and metabolic dysregulation (MetD; a measure of metabolic health and precursor to many medical illnesses). Though AL and MetD are associated with poor somatic health outcomes, little is known regarding their relationship with antidepressant-treatment outcomes. Methods We determined pre-treatment AL and MetD in 67 healthy controls and 34 unmedicated, medically healthy MDD subjects. Following this, MDD subjects completed 8-weeks of open-label selective serotonin reuptake inhibitor (SSRI) antidepressant treatment and were categorized as ‘Responders’ (⩾50% improvement in depression severity ratings) or ‘Non-responders’ (<50% improvement). Logistic and linear regressions were performed to determine if pre-treatment AL or MetD scores predicted SSRI-response. Secondary analyses examined cross-sectional differences between MDD and control groups. Results Pre-treatment AL and MetD scores significantly predicted continuous antidepressant response (i.e. absolute decreases in depression severity ratings) (p = 0.012 and 0.014, respectively), as well as post-treatment status as a Responder or Non-responder (p = 0.022 and 0.040, respectively), such that higher pre-treatment AL and MetD were associated with poorer SSRI-treatment outcomes. Pre-treatment AL and MetD of Responders were similar to Controls, while those of Non-responders were significantly higher than both Responders (p = 0.025 and 0.033, respectively) and Controls (p = 0.039 and 0.001, respectively). Conclusions These preliminary findings suggest that indices of metabolic and hypothalamic-pituitary-adrenal-axis dysregulation are associated with poorer SSRI-treatment response. To our knowledge, this is the first study to demonstrate that these markers of medical disease risk also predict poorer antidepressant outcomes.

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Reduced Latency to First Antidepressant Treatment in Italian Patients with a More Recent Onset of Major Depressive Disorder

10.26226/morressier.5885d713d462b8028d891057 ◽

2017 ◽

Author(s):

Benedetta Maria Grancini

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Antidepressant Treatment ◽

Major Depressive ◽

Recent Onset

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Extension Study of Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment

Case Medical Research ◽

10.31525/ct1-nct04000009 ◽

2019 ◽

Author(s):

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Antidepressant Treatment ◽

Extension Study ◽

Inadequate Response ◽

Major Depressive

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Faculty Opinions recommendation of Early prediction of acute antidepressant treatment response and remission in pediatric major depressive disorder.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1160666.622058 ◽

2009 ◽

Author(s):

Charles Zeanah

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Treatment Response ◽

Antidepressant Treatment ◽

Early Prediction ◽

Major Depressive

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Gender Differences in Transcranial Magnetic Stimulation Treatment Outcomes for Major Depressive Disorder: A Single Institution Experience

Brain Stimulation ◽

10.1016/j.brs.2020.06.033 ◽

2020 ◽

Vol 13 (6) ◽

pp. 1847

Author(s):

Ganesh Maniam ◽

Cinthya Vigil ◽

Amy Stark

Keyword(s):

Gender Differences ◽

Major Depressive Disorder ◽

Transcranial Magnetic Stimulation ◽

Depressive Disorder ◽

Treatment Outcomes ◽

Magnetic Stimulation ◽

Single Institution ◽

Major Depressive

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Reduced latency to first antidepressant treatment in Italian patients with a more recent onset of major depressive disorder

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.715 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S529-S529

Author(s):

B. Grancini ◽

B. Dell’Osso ◽

L. Cremaschi ◽

F. De Cagna ◽

B. Benatti ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Antidepressant Treatment ◽

Stressful Events ◽

Major Depressive ◽

Recent Onset ◽

Valid Predictor ◽

Before And After ◽

Competing Interest ◽

Year 2000

IntroductionMajor depressive disorder (MDD) is a prevalent burdensome disease, which frequently remains untreated. The duration of untreated illness (DUI) is modifiable parameter and a valid predictor of outcome. Previous investigation in patients with MDD revealed a DUI of different years, while recent reports have documented a reduction of DUI across time, in patients with different psychiatric disorders.Objectives/aimsThe present study was aimed to investigate potential differences in terms of DUI and related variables in patients with MDD across time.MethodsAn overall sample of 188 patients with MDD was divided in two subgroups on the basis of their epoch of onset (onset before and after year 2000). DUI and other onset-related variables were assessed through a specific questionnaire and compared between the two subgroups.ResultsThe whole sample showed a mean DUI of approximately 4.5 years, with a lower value in patients with more recent onset compared to the other subgroup (27.1 ± 42.6 vs. 75.8 ± 105.2 months, P < .05). Moreover, patients with onset after 2000 reported higher rates of onset-related stressful events and lower ones for benzodiazepines prescription (65% vs. 81%; P = 0.02; 47% vs. 30%; P = 0.02).ConclusionsThe comparison of groups with different epochs of onset showed a significant reduction in terms of DUI and benzodiazepines prescription, and a higher rate of onset-related stressful events in patients with a more recent onset. Reported findings are of epidemiologic and clinical relevance in order to evaluate progress and developments in the diagnostic and therapeutic pathways of MDD in Italian and other countries.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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