scholarly journals Predictive factors for relapse of epileptic spasms after adrenocorticotropic hormone therapy in West syndrome

2016 ◽  
Vol 38 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Yumiko Hayashi ◽  
Harumi Yoshinaga ◽  
Tomoyuki Akiyama ◽  
Fumika Endoh ◽  
Yoko Ohtsuka ◽  
...  
Keyword(s):  
Hormone Therapy ◽  
Predictive Factors ◽  
Adrenocorticotropic Hormone ◽  
West Syndrome ◽  
Epileptic Spasms

scholarly journals Efficacy of long‐term adrenocorticotropic hormone therapy for West syndrome: A retrospective multicenter case series

2021 ◽  
Author(s):  
Shimpei Baba ◽  
Tohru Okanishi ◽  
Yoichiro Homma ◽  
Takeshi Yoshida ◽  
Tomohide Goto ◽  
...  
Keyword(s):  
Hormone Therapy ◽  
Adrenocorticotropic Hormone ◽  
Case Series ◽  
West Syndrome

Efficacy and Side Effects of Short-Term Alternate-Day Adrenocorticotropic Hormone Therapy for Epileptic Spasms in Symptomatic Epilepsy

Epilepsia ◽  
1996 ◽  
Vol 37 (s3) ◽  
pp. 88-89 ◽  
Author(s):  
Katsumi Imai ◽  
Kazumasa Otani ◽  
Keiko Yanagihara ◽  
Megumi Goto ◽  
Yasuyuki Futagi ◽  
...  
Keyword(s):  
Side Effects ◽  
Hormone Therapy ◽  
Adrenocorticotropic Hormone ◽  
Short Term ◽  
Epileptic Spasms ◽  
Symptomatic Epilepsy

scholarly journals Effect of adrenocorticotropic hormone therapy for epileptic spasms developing after the age of 1 year

Seizure ◽  
2014 ◽  
Vol 23 (7) ◽  
pp. 521-526 ◽  
Author(s):  
Miho Fukui ◽  
Shuichi Shimakawa ◽  
Ichiro Kuki ◽  
Hisashi Kawawaki ◽  
Yukiko Mogami ◽  
...  
Keyword(s):  
Hormone Therapy ◽  
Adrenocorticotropic Hormone ◽  
Epileptic Spasms

scholarly journals Reduction in Glutamine/Glutamate Levels in the Cerebral Cortex after Adrenocorticotropic Hormone Therapy in Patients with West Syndrome

2014 ◽  
Vol 232 (4) ◽  
pp. 277-283 ◽  
Author(s):  
Mitsutoshi Munakata ◽  
Noriko Togashi ◽  
Osamu Sakamoto ◽  
Kazuhiro Haginoya ◽  
Yasuko Kobayashi ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Hormone Therapy ◽  
Adrenocorticotropic Hormone ◽  
West Syndrome

Therapeutic efficacy and adverse effects of adrenocorticotropic hormone therapy in west syndrome: Differences in dosage of adrenocorticotropic hormone, onset of age, and cause

2006 ◽  
Vol 148 (4) ◽  
pp. 485-488 ◽  
Author(s):  
Shin-ichiro Hamano ◽  
Shintaro Yamashita ◽  
Manabu Tanaka ◽  
Satoshi Yoshinari ◽  
Motoyuki Minamitani ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Hormone Therapy ◽  
Therapeutic Efficacy ◽  
Adrenocorticotropic Hormone ◽  
West Syndrome

FOCAL EPILEPTIC SPASMS INVOLVING ONE LEG EMERGING DURING THE CLINICAL COURSE OF WEST SYNDROME (WS)

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
K Tanoue ◽  
H Oguni ◽  
N Nakayama ◽  
K Sasaki ◽  
Y Ito ◽  
...  
Keyword(s):  
Clinical Course ◽  
West Syndrome ◽  
Epileptic Spasms

scholarly journals A conundrum of West syndrome, behavioural problems and parental expressed emotions: a case report

2020 ◽  
Vol 33 (5) ◽  
pp. e100111
Author(s):  
Yogender Kumar Malik ◽  
Nidhi Chauhan ◽  
Akhilesh Sharma ◽  
Susanta Padhy
Keyword(s):  
Case Report ◽  
Early Recognition ◽  
West Syndrome ◽  
Behavioural Problems ◽  
Optimal Outcome ◽  
Optimal Care ◽  
Epileptic Spasms ◽  
Expressed Emotions ◽  
Neurodevelopmental Problems ◽  
The Ideal

West syndrome (WS) is the most common epileptic syndrome in infancy characterised by epileptic spasms, hypsarrhythmia and neurodevelopmental problems. Epileptic spasms remain in many ways a conundrum, and the ideal intervention, as well as how to screen patients to provide optimal care and certainly its genetic cause, remains puzzling. It is important to screen infants for early recognition and intervention to achieve the optimal outcome. We hereby discuss the approach to management of a boy aged 4½ years old with WS and behavioural problems and of parental expressed emotions.

scholarly journals Cytokines in cerebrospinal fluid of children with West syndrome

2012 ◽  
Vol 18 (2) ◽  
pp. 63-66 ◽  
Author(s):  
MA Dias de Sousa ◽  
RCF Bonatti ◽  
V Rodrigues Jr ◽  
DS Azevedo ◽  
MHA Santos ◽  
...  
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Therapeutic Response ◽  
West Syndrome ◽  
Symptomatic Group ◽  
Structural Abnormalities ◽  
Neurophysiological Mechanisms ◽  
Clinical Eeg ◽  
Necrosis Factor ◽  
Pathophysiologic Mechanisms

In this study we aimed to determine the levels of tumor necrosis factor beta (TNF-b), interleukin (IL) 1-beta (IL-1b), IL-5, IL-10, and interferon gamma (IFN-g ) in CSF from children during the onset of West syndrome (WS). We observed elevated levels of IL-1b and IFN-g correlated to clinical, EEG, therapeutic response, and follow-up suggesting the involvement of immune response in WS. These results suggest that inflammatory and immunologic mediators may play a role in the pathophysiologic mechanisms of infantile spasms. Our findings may explain the perfusion and cognitive disfunctions and actions of adrenocorticotropic hormone (ACTH), corticosteroids, and intravenous immunoglobulin (IVIg) observed in WS. In conclusion, WS results from association of neurophysiological mechanisms and structural abnormalities with participation of cytokines mainly in symptomatic group.

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