Elimination of amyloid precursor protein in senile plaques in the brain of a patient with Alzheimer-type dementia and Down syndrome

2019 ◽  
Vol 41 (1) ◽  
pp. 106-110
Author(s):  
Yasuhiro Arai ◽  
Yuji Iwasaki ◽  
Toshihiro Suzuki ◽  
Shuuhei Ide ◽  
Makiko Kaga
Keyword(s):  
Down Syndrome ◽  
Amyloid Precursor Protein ◽  
Senile Plaques ◽  
Precursor Protein ◽  
Alzheimer Type ◽  
Alzheimer Type Dementia ◽  
The Brain

P2-123: The deposition of Aß40 in the brain is pathognomonic for Alzheimer-type dementia in Down syndrome

2009 ◽  
Vol 5 (4S_Part_10) ◽  
pp. P297-P298 ◽  
Author(s):  
Pedro Pesini ◽  
Ana M. Lacosta ◽  
Manuel Sarasa
Keyword(s):  
Down Syndrome ◽  
Alzheimer Type ◽  
Alzheimer Type Dementia ◽  
The Brain

AMYLOID PRECURSOR PROTEIN IN SENILE PLAQUES OF ALZHEIMER DISEASE

The Lancet ◽  
1988 ◽  
Vol 332 (8613) ◽  
pp. 746 ◽  
Author(s):  
George Perry ◽  
Sandra Lipphardt ◽  
Madhu Kancherla ◽  
Pierluigi Gambetti ◽  
Linda Maggiora ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Amyloid Precursor Protein ◽  
Senile Plaques ◽  
Precursor Protein

scholarly journals Expression of Neuronal mRNAs in Alzheimer Type Degeneration of the Nervous System

1989 ◽  
Vol 16 (S4) ◽  
pp. 477-482 ◽  
Author(s):  
Arthur W. Clark ◽  
Irma M. Parhad
Keyword(s):  
Gene Expression ◽  
Nervous System ◽  
Amyloid Precursor Protein ◽  
Cytoskeletal Proteins ◽  
Precursor Protein ◽  
Alzheimer Type

ABSTRACT:There is extensive evidence for decrements of gene expression in AD, at several levels in the process. There is also evidence for increments of expression of some genes. Message for the amyloid precursor protein (APP), for example, is elevated in surviving neurons of certain subcortical populations in AD. We evaluated expression of message for APP as well as for certain neuronal and glial cytoskeletal proteins in the cortex of six cases of AD. Neuronal mRNAs, including that for APP, were significantly decreased when compared with control cortex, whereas the glial mRNA was increased. We have projected studies to determine the evolution of these mRNA decrements in Alzheimer-type degeneration. The rationale for these studies and preliminary findings are discussed.

Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome

2002 ◽  
Vol 326 (1) ◽  
pp. 64-66 ◽  
Author(s):  
Kozo Motonaga ◽  
Masayuki Itoh ◽  
Laurence E. Becker ◽  
Yu-ichi Goto ◽  
Sachio Takashima
Keyword(s):  
Down Syndrome ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Elevated Expression

Lewy bodies in the brain of two members of a family with the 717 (Val to Ile) mutation of the amyloid precursor protein gene

1994 ◽  
Vol 172 (1-2) ◽  
pp. 77-79 ◽  
Author(s):  
P.L. Lantos ◽  
I.M.K. Ovenstone ◽  
J. Johnson ◽  
C.A. Clelland ◽  
Penelope Roques ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Protein Gene ◽  
Lewy Bodies ◽  
Precursor Protein ◽  
Amyloid Precursor Protein Gene ◽  
The Brain

scholarly journals Platelet Amyloid Precursor Protein Abnormalities in Mild Cognitive Impairment Predict Conversion to Dementia of Alzheimer Type

2003 ◽  
Vol 60 (12) ◽  
pp. 1740 ◽  
Author(s):  
Barbara Borroni ◽  
Francesca Colciaghi ◽  
Carlo Caltagirone ◽  
Luca Rozzini ◽  
Laura Broglio ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type
Sign in / Sign up

Export Citation Format

Share Document