Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia

2004 ◽  
Vol 1029 (2) ◽  
pp. 200-206 ◽  
Author(s):  
Hideo Shichinohe ◽  
Satoshi Kuroda ◽  
Hiroshi Yasuda ◽  
Tatsuya Ishikawa ◽  
Masaru Iwai ◽  
...  
Keyword(s):  
Free Radical ◽  
Brain Ischemia ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Neuroprotective Effects ◽  
Focal Brain Ischemia

scholarly journals Neuroprotective Effects of Edaravone: a Novel Free Radical Scavenger in Cerebrovascular Injury

2006 ◽  
Vol 12 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Hiroshi Yoshida ◽  
Hidekatsu Yanai ◽  
Yoshihisa Namiki ◽  
Kayoko Fukatsu-Sasaki ◽  
Nobuyuki Furutani ◽  
...  
Keyword(s):  
Free Radical ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Neuroprotective Effects ◽  
Cerebrovascular Injury

OPTIMASI KONDISI EKSTRAKSI SENYAWA AKTIF ANTIOKSIDAN DARI BIJI ANGGUR

2019 ◽  
Vol 3 (2) ◽  
pp. 35
Author(s):  
Kartini Kartini ◽  
Azminah Azminah
Keyword(s):  
Free Radical ◽  
Optimum Condition ◽  
Active Compound ◽  
Grape Seed ◽  
Free Radical Scavenger ◽  
Water Bath ◽  
Radical Scavenger ◽  
Optimum Conditions ◽  
Ethanolic Solution ◽  
Reduced Pressure

In order to prepare standardized extract, optimization of extraction conditions of grape seed has been done. These conditions are type of menstrum (50, 70 and 96% of ethanolic solution), length of extraction (1, 2 and 4 hours) also method of evaporation (reduced pressure and opened air). Activity on free radical scavenger used as parameters to determine optimum conditions. Based on EC50 (concentration which scavenge 50% amount of free radical) can be concluded that optimum condition for extracting antioxidant active compound from grape seed are 70% ethanolic solution as menstrum, length of extraction 1 hour and evaporation on opened air use water bath.

scholarly journals Possible Protective Role of Melatonin in Pediatric Infectious Diseases and Neurodevelopmental Pathologies

2020 ◽  
Vol 10 (01) ◽  
pp. e104-e109
Author(s):  
Antonio Molina-Carballo ◽  
Antonio Emilio Jerez-Calero ◽  
Antonio Muñoz-Hoyos
Keyword(s):  
Endothelial Cell ◽  
Free Radical ◽  
Chronic Administration ◽  
Protective Role ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Energetic Metabolism ◽  
Beneficial Effects ◽  
Molecular Crosstalk

AbstractMelatonin, produced in every cell that possesses mitochondria, acts as an endogenous free radical scavenger, and improves energetic metabolism and immune function, by complex molecular crosstalk with other intracellular compounds. There is greatly increasing evidence regarding beneficial effects of acute and chronic administration of high melatonin doses, in infectious, developmental, and degenerative pathologies, as an endothelial cell and every cell protectant.

scholarly journals Intravenous Edaravone plus Therapeutic Hypothermia Offers Limited Neuroprotection in the Hypoxic-Ischaemic Newborn Piglet

Neonatology ◽  
2020 ◽  
pp. 1-8
Author(s):  
Satoshi Hamano Yamato ◽  
Shinji Nakamura ◽  
Yinmon Htun ◽  
Makoto Nakamura ◽  
Wataru Jinnai ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Cerebral Blood Volume ◽  
Free Radical Scavenger ◽  
Newborn Piglet ◽  
Radical Scavenger ◽  
Neuroprotective Effects ◽  
The Mean ◽  
Additional Therapy ◽  
Inspired Oxygen ◽  
Histopathological Score

<b><i>Background:</i></b> Therapeutic hypothermia (TH) is a standard therapy for neonatal hypoxic-ischaemic encephalopathy. One potential additional therapy is the free radical scavenger edaravone (EV; 3-methyl-1-phenyl-2-pyrazolin-5-one). <b><i>Objectives and Methods:</i></b> This study aimed to compare the neuroprotective effects of edaravone plus therapeutic hypothermia (TH + EV) with those of TH alone after a hypoxic-ischaemic insult in the newborn piglet. Anaesthetized piglets were subjected to 40 min of hypoxia (3–5% inspired oxygen), and cerebral ischaemia was assessed using cerebral blood volume. Body temperature was maintained at 39.0 ± 0.5°C in the normothermia group (NT, <i>n</i> = 8) and at 33.5 ± 0.5°C (24 h after the insult) in the TH (<i>n</i> = 7) and TH + EV (3 mg/kg intravenous every 12 h for 3 days after the insult; <i>n</i> = 6) groups under mechanical ventilation. <b><i>Results:</i></b> Five days after the insult, the mean (standard deviation) neurological scores were 10.9 (5.7) in the NT group, 17.0 (0.4) in the TH group (<i>p</i> = 0.025 vs. NT), and 15.0 (3.9) in the TH + EV group. The histopathological score of the TH + EV group showed no significant improvement compared with that of the other groups. <b><i>Conclusion:</i></b> TH + EV had no additive neuroprotective effects after hypoxia-ischaemia in neurological and histopathological assessments.

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