Real‐world safety of the novel, free radical scavenger edaravone for amyotrophic lateral sclerosis patients: Data from the post‐marketing surveillance SUNRISE Japan

2021 ◽  
Author(s):  
Kaoru Ishizaki ◽  
Kenta Yoshimura ◽  
Kengo Yoshida ◽  
Masao Matsuda ◽  
Yutaka Kawaguchi ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Free Radical ◽  
Real World ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
The Novel ◽  
Post Marketing Surveillance ◽  
Post Marketing ◽  
Lateral Sclerosis

The Novel Free Radical Scavenger, Edaravone, Increases Neural Stem Cell Number Around the Area of Damage Following Rat Traumatic Brain Injury

2009 ◽  
Vol 16 (4) ◽  
pp. 378-389 ◽  
Author(s):  
Tatsuki Itoh ◽  
Takao Satou ◽  
Shozo Nishida ◽  
Masahiro Tsubaki ◽  
Shigeo Hashimoto ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cell ◽  
Free Radical ◽  
Brain Injury ◽  
Neural Stem Cell ◽  
Cell Number ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
The Novel

CHARACTERISTICS AND THERAPEUTIC EFFECTS OF THE NOVEL FREE RADICAL SCAVENGER – EDARAVONE

2020 ◽  
Vol 04 (05) ◽  
pp. 17-20
Author(s):  
Mirza Mikayil Aliyev ◽  
◽  
Ulduz Yunis Safarova ◽  
Shafiqa Jahangir Jafarova ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Arachidonic Acid ◽  
Free Radical ◽  
Hydroxyl Radicals ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Therapeutic Effects ◽  
The Novel ◽  
Prostacyclin Production

Edaravone is the first free radical scavenger which approved clinically and has an ability to decrease the level of free radicals in cells. Edaravone is a strong antioxidant, which can protect different cells (e.g. endothelial cells) against damage by ROS by inhibiting the lipoxygenase metabolism of arachidonic acid, by trapping hydroxyl radicals, by increasing prostacyclin production, by inhibiting alloxan-induced lipid peroxidation, etc. Because of that, Edaravone is used in treatment of diseases which are associated with oxidative stress. Key words: edaravone, free radical, antioxidant, neuroprotective agent, oxidative stress

OPTIMASI KONDISI EKSTRAKSI SENYAWA AKTIF ANTIOKSIDAN DARI BIJI ANGGUR

2019 ◽  
Vol 3 (2) ◽  
pp. 35
Author(s):  
Kartini Kartini ◽  
Azminah Azminah
Keyword(s):  
Free Radical ◽  
Optimum Condition ◽  
Active Compound ◽  
Grape Seed ◽  
Free Radical Scavenger ◽  
Water Bath ◽  
Radical Scavenger ◽  
Optimum Conditions ◽  
Ethanolic Solution ◽  
Reduced Pressure

In order to prepare standardized extract, optimization of extraction conditions of grape seed has been done. These conditions are type of menstrum (50, 70 and 96% of ethanolic solution), length of extraction (1, 2 and 4 hours) also method of evaporation (reduced pressure and opened air). Activity on free radical scavenger used as parameters to determine optimum conditions. Based on EC50 (concentration which scavenge 50% amount of free radical) can be concluded that optimum condition for extracting antioxidant active compound from grape seed are 70% ethanolic solution as menstrum, length of extraction 1 hour and evaporation on opened air use water bath.

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