Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia

2007 ◽  
Vol 1153 ◽  
pp. 58-67 ◽  
Author(s):  
Slavianka Georgieva Moyanova ◽  
Lidia Vasileva Kortenska ◽  
Rumiana Gesheva Mitreva ◽  
Vyara Dincova Pashova ◽  
Richard Teke Ngomba ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Mk 801 ◽  
Endothelin 1 ◽  
Multimodal Assessment ◽  
Focal Brain Ischemia

Postischemic therapy with MK-801 (dizocilpine) in a primate model of transient focal brain ischemia

1996 ◽  
Vol 29 (2-3) ◽  
pp. 193-210 ◽  
Author(s):  
Roland N. Auer ◽  
Stuart G. Coupland ◽  
Gregor W. Jason ◽  
David P. Archer ◽  
Jacqueline Payne ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Primate Model ◽  
Mk 801 ◽  
Focal Brain Ischemia

scholarly journals Spreading depolarizations in the rat endothelin-1 model of focal cerebellar ischemia

2019 ◽  
Vol 40 (6) ◽  
pp. 1274-1289 ◽  
Author(s):  
Ana I Oliveira-Ferreira ◽  
Sebastian Major ◽  
Ingo Przesdzing ◽  
Eun-Jeung Kang ◽  
Jens P Dreier
Keyword(s):  
Blood Flow ◽  
Purkinje Cells ◽  
Cerebellar Cortex ◽  
Brain Ischemia ◽  
Regional Blood Flow ◽  
Focal Ischemia ◽  
Cell Counting ◽  
High Susceptibility ◽  
Endothelin 1 ◽  
Focal Brain Ischemia

Focal brain ischemia is best studied in neocortex and striatum. Both show highly vulnerable neurons and high susceptibility to spreading depolarization (SD). Therefore, it has been hypothesized that these two variables generally correlate. However, this hypothesis is contradicted by findings in cerebellar cortex, which contains highly vulnerable neurons to ischemia, the Purkinje cells, but is said to be less susceptible to SD. Here, we found in the rat cerebellar cortex that elevated K+ induced a long-lasting depolarizing event superimposed with SDs. Cerebellar SDs resembled those in neocortex, but negative direct current (DC) shifts and regional blood flow responses were usually smaller. The K+ threshold for SD was higher in cerebellum than in previous studies in neocortex. We then topically applied endothelin-1 (ET-1) to the cerebellum, which is assumed to cause SD via vasoconstriction-induced focal ischemia. Although the blood flow decrease was similar to that in previous studies in neocortex, the ET-1 threshold for SD was higher. Quantitative cell counting found that the proportion of necrotic Purkinje cells was significantly higher in ET-1-treated rats than sham controls even if ET-1 had not caused SDs. Our results suggest that ischemic death of Purkinje cells does not require the occurrence of SD.

scholarly journals Sodium time course using23Na MRI in reversible focal brain ischemia in the monkey

2009 ◽  
Vol 30 (1) ◽  
pp. 219-223 ◽  
Author(s):  
George C. LaVerde ◽  
Charles A. Jungreis ◽  
Edwin Nemoto ◽  
Fernando E. Boada
Keyword(s):  
Brain Ischemia ◽  
Time Course ◽  
Focal Brain Ischemia

scholarly journals Correction to: Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats

2018 ◽  
Vol 224 (2) ◽  
pp. 739-740 ◽  
Author(s):  
Shotaro Otsuka ◽  
Harutoshi Sakakima ◽  
Takuto Terashi ◽  
Seiya Takada ◽  
Kazuki Nakanishi ◽  
...  
Keyword(s):  
Brain Damage ◽  
Brain Ischemia ◽  
Neuronal Apoptosis ◽  
Focal Brain Ischemia

IONOTROPIC GLUTAMATE RECEPTOR RESPONSES DURING EARLY STAGES OF FOCAL BRAIN ISCHEMIA

1993 ◽  
Vol 52 (3) ◽  
pp. 274
Author(s):  
C. A. Pardo ◽  
L. I. Martin ◽  
L. H. Monsein ◽  
C. D. Blackstone ◽  
R. N. Bryan
Keyword(s):  
Glutamate Receptor ◽  
Brain Ischemia ◽  
Ionotropic Glutamate Receptor ◽  
Early Stages ◽  
Focal Brain Ischemia

scholarly journals Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the mongolian gerbil

2011 ◽  
Vol 4 (1) ◽  
pp. 35 ◽  
Author(s):  
Junichi Yamane ◽  
Satoru Ishibashi ◽  
Masanori Sakaguchi ◽  
Toshihiko Kuroiwa ◽  
Yonehiro Kanemura ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Brain Ischemia ◽  
Functional Recovery ◽  
Mongolian Gerbil ◽  
Neural Stem Progenitor Cells ◽  
Focal Brain Ischemia

scholarly journals Exercise Preconditioning Attenuates Neurological Injury by Preserving Old and Newly Formed HSP72-Containing Neurons in Focal Brain Ischemia Rats

2019 ◽  
Vol 16 (5) ◽  
pp. 675-685
Author(s):  
Yu-Lin Wang ◽  
Cheng-Hsien Lin ◽  
Chi-Chun Chen ◽  
Ching-Ping Chang ◽  
Kao-Chang Lin ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Neurological Injury ◽  
Exercise Preconditioning ◽  
Focal Brain Ischemia

Aromatase and neuroinflammation in rat focal brain ischemia

2017 ◽  
Vol 174 ◽  
pp. 225-233 ◽  
Author(s):  
Yu H. Zhong ◽  
Jasbeer Dhawan ◽  
Joel A. Kovoor ◽  
John Sullivan ◽  
Wei X. Zhang ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Focal Brain Ischemia
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